Who Speaks for Teenagers Tormented By Skipper Periods, Facial Hair, and Ovarian Cysts?


 

Majid Ali, M.D.

140 West End Avenue,   Suite 1-H, New York, NY 10023

212-873-2444 344

344 Prospect Avenue, Suite 3-C, Hackensack, NJ. 07610

201-996-0027

Askipm@aol.com


 

  The GIO Path of Healing

The Core Goals of No-Cost Ali GIO Health and Healing Course

For Individuals Willing and Able to Learn Valuable Information About Healthful Life Span to:

1. To learn and understand the uneven medical playing fields which turn corporate medical America into sellers and patients into buyers

(In Medical Seller-Buyer Dealings, the Short-Changed Party Is Always the Buyer.) 

2. Level their medical playing fields in countering corporate medical America;

3. To study and learn well the philosophy and science of holism in health and healing;

4. To effectively counter corporate deceptions as well as idealogical distortions of ill-informed health activists;

5. To study and learn well the philosophy and science of holism in health and healing;

6. To undertake, for love of learning, a  path of self-learning to self-empowerment to self-healing

5. Through personal observations learn how the sound science of holism in health and healing To as Become their own well-informed personal health advocates;

6. To learn to preserve health, prevent disease, and reverse chronic diseases by becoming their own primary physicians;

7. To remain students of the above subjects and yet serve as other as teachers in the  field.

******

GIO Path of Healing Is a Self-Learning to Self-Empowering to Self- Healing with a Sharp Focus on

1. Self-Education

2. Self-Empowerment

3. Health Preservation

4. Disease Prevention, and

5. Reversing chronic disease.


I must be kind to my body so my body can be kind to me.


Ali GIO Path of Health and Healing Course is a free public service health course designed for patient education and patient empowerment.

Ali GIO Path of Health and Healing Course is suitable for students of all descriptions – from elementary school to doctorate students, from patients to physicians, from public health policy makers to philosophers of health, hope, and healing.


 

Seven Parts of Health and Healing Course

  1. Ali GIO Health and Healing Course Introduction – Three Root Problems, Three Sets of Solutions

  2. Ali GIO Health and Healing Course, Part One – Self-learning and Self-Empowering for Self-Healing Chronic Disease

  3. Ali GIO Health and Healing Course, Part Two –Strong Scientific Claims Require Strong Scientific Evidence

  4. Ali GIO Health and Healing Course, Part Three – Energy Thinking for Energy Healing

  5. Ali GIO Health and Healing Course, Part Four – Safety First, Acute and Chronic Diseases

  6. Ali GIO Health and Healing Course, Part Five – Top Seven for Gut, Oxygen, and Insulin

  7. Ali GIO Health and Healing Course, Part Six – The Gut-Liver-Brain Connections

  8. Ali GIO Health Healing Course, Part Seven – The Spiritual Dimension and Course Study Materials


Why Do I Focus on Oxygen, Gut, and Insulin in All Matters of Health and Healing?

My Simple Answer: Because in my sixty-one year study, research, teaching, publications, and clinical practice,  I observed the best long-lasting results in all chronic diseases (including cancer) with my GIO philosophy and science of health and Healing with sharp focus on:

  1.      for gut ecology and gut microbiome

  2.   I      for insulin homeostasis 

  3.       Oxygen signaling (molecilar biology of  oxygen) 

To introduce readers to my academic background and qualifications to address all matters of health and healing:

  1. I am a surgeon (FRCS, Eng)-turned – pathologist (Columbia University, New York) -turned – nutritionist – turned clinical ecologist – turned integrationist;

  2. I am the solo author of all 12 volumes of The Principles and Practice of medicine  (1989-2009), and 27 other books (see my CV on this site for details).

  3. I published 215 papers (many with my research and clinical collaborators) in eminent medical journals (including Lancet, JAMA, Cancer, Kidney International, Am Heart Journal, Am J Clinical pathology, Archives of Pathology, Israeli Journal of Sciences, Environmental Medicine, and others). See my CV on this site for details).

  4. My CV includes a large number of publications on three subjects of molecular biology of oxygen, gut ecology and gut microbiome, and insulin homeostasis.


Where Do Acids in the Body Come From?

Excess Acidity Is Bad for Health and Contributes to All Diseases

I offer the above question as a “learning teaser.” The second of the above two statements is universally recognized and emphasized. As for the first statement, with rare exceptions, only diet is considered as source of acidity in the body. This is the most glaring example of neglect of real issues in my profession. Diet seldom, if ever, accounts for the main burden of total body acidity in chronic disease and unwellness.

In chronic illness,the main sources of excess acidity are:

  1. Gut ecology and gut microbiome
  2. Insulin homeostasis
  3.  Oxygen signaling (Molecular Biology of Oxygen 

The diet as the source of total body acidity is seldom a significant issue. Here is one of myriad ironies of the subject of acid-alkaline balance: People, even most doctors, attribute stomach conditions, such as gastritis, GERD, stomach and duodenal ulcers, esophagitis, and hiatal hernia, and heartburn (in common vernacular) as caused by acidity. The acidity in all of the above again comes from disruptions of:

  1. Gut ecology and gut microbiome
  2. Insulin homeostasis
  3.  Oxygen signaling (Molecular Biology of Oxygen 

I recognize the above as medical ironies. Next I recognize the medical tragedies: The prevailing medical teaching and standards completely neglect the above three matters. The patients pay a large price, often for years, because of the ignorance and neglect of medical practitioners.

 


 

Three primary mechanisms of cellular injury in all chronic diseases in Ali GIO Model of Health and Healing are:

  1. Disrupted Molecular Biology of Oxygen,

  2. Disrupted Oxygen signaling, and

  3. Disrupted Insulin Homeostasis and Insulin Signaling


 

ALI GIO HEALING – STRONG SCIENTIFIC CLAIMS REQUIRE STRONG SCIENTIFIC EVIDENCE

The central claim of Ali GIO model is that the three primary mechanisms of cellular injury in all chronic diseases are:

  1. Disrupted gut ecology and perverted degrees of gut fermentation (increased gut burden of gut flora;
  2. Disrupted insulin homeostasis; and gut ecology and perverted degrees of gut fermentation (increased gut burden of gut flora.
  3. Disrupted oxygen signaling and other aspects of molecular biology of oxygen

 

 

The GIO Philosophy and Science

                   G     for Gut

   

                   I      for in Insulin                             

                   O       for Oxygen

 


 

The above three are serious scientific claims that I make in Ali GIO Healing and form the basis of my next three scientific claims:

  1. No treatment plans for healing any chronic disease can be considered complete unless all disrupted oxygen signaling is restored to normal oxygen signaling.

  2. No treatment plans for healing any chronic disease can be considered complete unless all disrupted insulin signaling is restored to normal oxygen signaling.

  3. No treatment plans for healing any chronic disease can be considered complete unless all disrupted patterns of gut ecology and gut microbiome are restored to normal gut ecology and gut microbiome.

ALI GIO HEALTH & HEALING COURSE

VIDEO LIBRARY

The left side panel of all parts of ALI GIO Health and Healing presents in alphabetical order a large library of the author’s videos on diverse subjects covered in the series of articles. Please select a video of your interest and click on the video listing to learn from the video. Links below take you to a series of videos on the subjects of gut ecology and microbiome and insulin toxicity.

Readers will find this series very informative and useful.

 

Bowel Health Series

  1.  Bowel-Colon Health videos part 1

https://majidalimd.me/bowel-videos/

2.  Bowel-Colon Health videos part 2

https://majidalimd.me/bowel-videos-part-2/

Insulin Toxicity Video Series

https://majidalimd.me/insulin-toxicity-and-dysfunction-videos-part-1/


ALI GIO Library of Published Articles and Book

  1. Ali M. Oxidative regression to primordial cellular ecology. J Integrative Medicine 1998; 2:4-55.
  2. Ali M. Bradford R, Ali O, et al. Immunostaining of Candida organisms in peripheral blood blood smears (abstract) 1995, American Academy of Otolaryngic Allergy, Spring Meeting, Palm Desert, CA.
  3. Ali M. Ramanarayanan MP:  A computerized micro-ELISA assay for allergen-specific IgE antibodies.  Am J Clin Pathol, 81:591-601, 1984.
  4. Ali M. Ramanarayanan MP, Nalebuff DJ, Fadal RG, Willoughby JW:  Serum concentrations of allergen-specific IgG antibodies in inhalant allergy: effect of specific immunotherapy.  Am J Clin Pathol, 80:290-299, 1983.
  5. Ali M. Respiratory-to-fermentative shift in immune-inflammatory disorders with energy deficit. Townsend Letter. 2004; 253;64-65.
  6. Ali M. Krebs cycle impairment – molecular biology of  oxygen. communication. Communication E-published. Nature. 2014;515:431.
  7. Ali M. Ali O. Oxidative coagulopathy in fibromyalgia and chronic fatigue syndrome. Am J Clin Pathol  1999; 112:566-7.Ali M. Krebs cycle impairment – molecular biology of  oxygen. communication. Communication E-published. Nature. 2014;515:431.
  8. Ali M. Oxygen and Aging. . (2nd ed.) New York, Canary 21 Press. 2004.
  9. Ali M. Spontaneity of oxidation in Nature and Aging. Monograph). Teaneck, New Jersey, U.S.A. 1983.
  10. Ali M. Hurt human habitat and energy deficit—Healing Through Restoration of Krebs cycle chemistry. Townsend Letter-The examiner of Alternative Medicine. 2006; 279:112-115.
  11. Ali M. The Principles and Practice of Integrative Medicine Volume  III: Pathobiology by Micro-Ecologic Cellular and Macro-Ecologic Tissue-Organ Systems 1999.  New York. Canary 21 Press. 1999.
  12. Ali M. The Principles and Practice of Integrative Medicine Volume  IV: Pathobiology by Micro-Ecologic Cellular and Macro-Ecologic Tissue-Organ Systems 1999.  New York. Canary 21 Press. 1999.
  13. Ali M. Altered States of Bowel Ecology. Monograph. Teaneck, New Jersey.1980.
  14. Ali M. The dysox model of aging.  Townsend Letter for Doctors. and Patients.2005;269:130-134.
  15. Ali M. The dysox model of aging.  Townsend Letter for Doctors and Patients.2005;269:130-134.
  16. Ali M. Obesity is cellular oxygen defunction state. Aging Healthfully Healthfully.  2004;5:2-19.
  17. Ali M. The oxidative-dysoxygenative perspective of allergic disorders. J Integrative Med. 2000; 4:1-17.
  18. Ali M. Beyond insulin resistance and syndrome X: The oxidative-dysoxygenative insulin dysfunction (ODID) model. J Capital University of Integrative Medicine. 2001;1:101-141.
  19. Ali M. The Dysox Model of Diabetes and De-Diabetization Potential. Townsend Letter-The examiner of Alternative Medicine. 2007; 286:137-145.
  20. Ali M. Oxygen, Insulin Toxicity, Inflammation, and  the Clinical Benefits of Chelation. Part I. Townsend Letter-The examiner of Alternative Medicine. 2009;315:105-109. Ali M. Insulin Reduction and EDTA Chelation: Two Potent and Complementary Approaches For Preventing and Reversing Coronary Disease. Oxygen, Insulin Toxicity, Inflammation, and the  Clinical Benefits of Chelation – Part II. Townsend Letter-The examiner of Alternative Medicine. 2010;323:74-79. June 2010.
  21. Ali M. Epidemic of Dysoxygenosis and the Metabolic Syndrome. In: The Principles and Practice of Integrative Medicine. Volume 5. Pp 246-256. Canary 21 Press. New York. 2005.
  22. Ali M. Insulin: the life span hormone for healthful aging. Townsend Letter. The Examiner of Alternative Medicine . 2018;416:54-59.
  23. Ali M. Death begins in the colon. Ali Academy.  http://aliacademy.org/problems_of_the_gut.htm
  24. Ali M. As roots are to roses, so the bowel to the brain. Diseaases begin in the fermenting colon.  Ali Academy.http://aliacademy.org/problems_of_the_gut.htm
  25. ‘Ali M. Ali M. Seed, Feed, and Weed Plan for Restoring Gut Flora   and Metabolic Health. Communication e-published in Nature. 2016;535:56-64.
  26. Chouchani ET, Pell VR, Guade E, et al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature.2014;515:431-435.
  27. Ali M. The agony and death of a cell. In: Syllabus of the Instruction Course of the American Academy of Environmental Medicine. Denver, Colorado, 1985.
  28. Ali M.The Principles and Practice of Integrative Medicine Volume X: Darwin, Oxygen Homeostasis, and  Oxystatic Therapies.  3 rd. Edi. (2009) New York. Institute of Integrative Medicine Press.
  29. Ali M. The Principles and Practice of Integrative Medicine Volume  XI: Darwin, Dysox, and Disease. 2000. 3rd. Edi. 2008. New York.  (2009) Institute of Integrative Medicine Press.
  30. Ali M. The Principles and Practice of Integrative Medicine Volume  XII: Darwin, Dysox, and Integrative Protocols. New York (2009). Institute of Integrative Medicine Press.
  31. Ali M. Petrochemical Illness and philic-phobic dysequilibrium in the Gulf of Mexico. Townsend Letter-The examiner of Alternative Medicine. 2010;76:79. November 2010.
  32. Ali M. Oxyphilic Nature Ali M. Fungal Infections and Oxyphile-Oxyphobic Conflicts. Communication e-published Nature. 2017.
  33. Ali M. The dysox model of renal insufficieny and improved renal function with oxystatic therapies. Townsend Letter for Doctors and Patients.2005;267:101-108.
  34. Ali M. Fischer S, Juco J, et al. The dysox model of coronay artery disease. Townsend Letter for Doctors and Patients. 2006;270/71:110-112.
  35. Ali M. The ADHD-Autism-Oxygen Connection: The Larger-Head-Smaller-Brain Scenario. Townsend Letter-The examiner of Alternative Medicine. April, 2008. http://www.townsendletter.com.
  36. Ali M. Oxygen model of Alzheimer’s disease. In . Oxygen and Aging. (2nd ed.) New York, Canary 21 Press. 2004.
  37. Ali M. Darwin Moms, Nursing Milk, and Antibiotic Resistance. In: Nature; 2016. 533:212.
  38. Progenitor stem cell progression model of autism (PSP Autism model). spectrum WordPress. 2016.
  39. Ali M.  Osteocrin, making connections, and autism. Communication e-published. Nature. 2016;539:242.
  40. Ali M. Chronic disease is evolution in reverse. Communication e-published. Nature. 2016. 530:268.
  41. Ali M. The Principles and Practice of Integrative Medicine Volume I: Nature’s Preoccupation With Complementarity and Contrariety. New York. Canary 21 Press. 1998. 2nd edition  2005.
  42. Ali M. The Principles and Practice of Integrative Medicine Volume  II: The History and Philosphy of Integrative Medicine. 2001.  New York. Canary 21 Press. 1998. 2nd edition  2006.
  1. Ali M. The Principles and Practice of Integrative Medicine Volume  III: Pathobiology by Micro-Ecologic Cellular and Macro-Ecologic Tissue-Organ Systems 1999.  New York. Canary 21 Press. 1999
  2. Ali M. The Principles and Practice of Integrative Medicine Volume  IV: Integrative Immunology and Allergy: The Oxidative-Dysoxygenative Perspective.  New York. Canary 21 Press. 1998. 2nd edition  2005.
  3. Ali M. The Principles and Practice of Integrative Medicine Volume  V: Integrative Nutritional Medicine: Nutrition Seen Through the Prism of Oxygen Homeostasis.  New York. Canary 21 Press. 1999. 2nd edition  2005.
  4. Ali M. Oxidative cell membrane disorder – Leaky Cell Membrane Disorder (monograph). Teaneck, NJ, 1987.
  5. Ali M. Darwin, oxidosis, dysoxygenosis, and integration. J Integrative Medicine 1999;3:11-16.
  6. Ali M:  Molecular basis for the use of antioxidants to regulate plasma membrane dynamics in allergic disorders.  abstracts, Annual Meeting of the American Academy of Otolaryngic Allergy, page 30, 199l.
  7. Ali M: Darwin, fatigue, and fibromyalgia.J Integrative Medicine 1999;3:5-10.
  8. Xu G, Buyun, SL, Buyun. Corrected prevalence of autism spectrum disorder among US children and adolescent. JAMA. 2018;319:505.
  9. He L, Si G, Huang J, et al. Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel. Nature. 2018;555:103-106.
  10. intestinal stem cell xxxxxxxxx xxxxxx / https://alihealing.org/2018/10/02/what-might-autism-teach-about-alzheimers-disease-ad-what-might-ad-teach-about-autism/

 

  1. Noctor SC, Martinez-Cerdeno V, Kriegstein AR. Contribution of intermediate progenitor cells to cortical histogenesis. Arch. Neurol. 2007;64:639-642.
  2. Seaberg RM, Van Der Kooy D. Stem and Progenitor cells. The premature desertion of rigorous definitions. Trends in Neurosciences. 2003;26:125-131.

56.Toriumi K, Mouri A, Narusawa S, et al. Prenatal NMDA Receptor Antagonism Impaired Proliferation of Neuronal Progenitor, Leading to Fewer Glutamatergic Neurons in the Prefrontal Cortex. Neuropsychopharmacology.2012;37: 1387-139./

  1. 57. Krakowiak P, Walker CK, Bremer AA, et al. Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. Pediatrics2012; 129(5): e1121–e1128.
  2. Bilbo SD, Tsang V. Enduring consequences of maternal obesity for brain inflammation and behavior of offspring. FASEB J 2010; 24(6): 2104–2115.
  3. Catalano P. The impact of gestational diabetes and maternal obesity on the mother and her offspring. J Dev Orig Health Dis2010; 1(04): 208–215.
  4. Van Lieshout R, Taylor V, Boyle M. Pre‐pregnancy and pregnancy obesity and neurodevelopmental outcomes in offspring: a systematic review. Obes Rev 2011; 12(5): e548–e559.
  5. Kosidou K,Kalman C, Gardner RM. Maternal Polycystic ovary syndrome and the risk of Autism spectrum disorders in the offspring. A population-based nationwide study in Sweden. Molecular Psychiatry.21:1441-144b.
  6. Cheslack-Postava K, Fallin MD. Beta adrenergic receptor gene variant and risk of autism in the AGRE cohort. Molecular Psychiatry. 2007;12:283-81.
  7. 63. Yazawa M, et al.Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Nature 471, 230–234 (2011).
  8. Sugimura R, Jha DK, Han Areum et al.  Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature. 2017;545;432-38.
  9. Lancaster, M. A. et al.Cerebral organoids model human brain development and microcephaly. Nature.2013;501, 373–379.
  10. Ataman B, Boulting G, Harmin DA, et al. Evolution of Osteocrin as an activity-regulated factor in the primate brain. Nature.  2016; 539: 242-247.
  11. Canter RG,Penney J, Tsai L-H. The road to restoring neural circuits for the treatment of Alzheimer’s disease. Nature. 2016;539:187-196.
  12. Mardinly, A. R. et al.Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons. Nature. 2016;531, 371–375.
  13. Quadrato G, Nguyen T, Macosko EZ, et al. Cell diversity and network dynamics in photosensitive human brain organoids. Nature. 2017;545:48-53.
  14. Birey F. Anderson J, Makinson CD. Et al.Assembly of functionally integrated human forebrain spheroids. Nature.2017;545:54-59.

71.Sweatt D, Layered-up regulation in the development developing brain.  Communication e-published.Nature. 2017;551:448-9.

  1. Kapp FG, Perlin JR, Hagedorn EJ, et al. Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. Nature. 2018;558:445-448.
  2. Lin G, Xu N, Xi, Paracrine signaling controls self-renewal of Drosophila intestinal stem cells.. Nature.2008;455.
  3. Ali M. Epigenetic and Clinical Implications of Neural Spheroids and Organoids In Treating Autism.. Communication. E-Published. Nature. 2017;545:54-59.
  4. Ali M Unpacking Brain Organoids and Spheroids for Delineating the Impeded Progenitor Cell Progression Model of the Autism Spectrum Disorder. Communicaion. E-Published. Nature. 2017; 545:48-53.
  5. Ali M.  Genetics and Comorbidities of the Autism Spectrum disorder. Communicaion. E-PublishedNature. 2017;543:507-512.
  6. Ali M.  Integration of Empirical Measures for Brain  Rejuvenation. Communicaion. E-Published.Nature. 2016;539:187.
  7. Ali M. Osteocrin, Making Connections, and Autism.  Communication e-published. Nature. 2016;539:242.
  8. Ali M.  Genetics and Comorbidities of the Autism Spectrum

disorder. Communicaion. E-Published Nature. 2017;543:507-512.

  1. Ali M.  Integration of Empirical Measures for Brain  Rejuvenation. Communication e-published. Nature. 2016;539:187.
  2. Ali M.Tribal Brain Model and Autism. Communication e-published. Nature. 2018;554:364-367.
  3. Ali M. Enteroendocrine Stem cells and Two Dimensions Enteroendocrine Dimension of the Autism Spectrum Disorder. Nature. 2018;555:103-106.
  4. Ali M. Epigenetic and Clinical Implications of Neural Spheroids and Organoids for integrative Management of Autism. Communication e-published in Nature. Nature.2017;545:54-59.
  5. Ali M. Hypothalamic Influences on Metabolism, Feeding, and Insulin. Nature. 2016;531:647-650.
  6. Ali  M. Irritable Bowel Syndrome and Seed,Feed, and Weed Approach. Communication e-published. Nature.  2016;533.
  7. Ali M. Darwin Moms , Nursing Milk, and Antibiotic Resistance. Communication e-published. Nature.2017;533:212.
  8. Ali M.Maternal Gut Microbes, Immune Connections, and Autism Circuits. Comment. E-Published. Nature. 2018; 549:528–532 & . 482-487.
  9. Ali M. Women-Like Men and Men-Like Women . Nature 533:206.
  10. Ali M.  Menstruating Mice and Human Reproductive Health. Nature. 2016.June.
  11. Ali M. 30. Workable Simplicity for Coping With Complexity of Diabetes. Nature.2016;534: 447
  12. Ali M. Reversing Diabetes – Acetate Mediates Metabolic   Syndrome. Nature.2016;534: 213.
  13. Ali M.
  14. Ali M. Recognized Empirtical Benefits of Methylation – What Next? Communication               e-published.Nature. 2016;369:373.
  15. Ali M. Darkfield Ali M. The Crab, Oxygen and Cancer. Volume I: The Dysox Model of Cancer.  2007.  New York, Canary 21 Press. Pages 114-116.
  1. Ali M. Cell Membrane Dysregulation. Syllabus. American Academy of Environmental Medicine. 1988. 13th Instructional Course. Cleveland, Ohio. pp 109-137.
  2. https://www.cdc.gov/mold/stachy.htm.
  3. Bitnun A, Nosal RM. Stachybotrys chartarum (atra)contamination of the indoor environment: Health implications. Paediatr Child Health. 1999;4:125-129.
  4. Shaw, W., et. al. Increased Urinary Excretion of Analogs of Krebs Cycle Metabolites and Arabinose in Two Brothers with Autistic Features. Clin Chem 41:1094-1104, 1995. 99. Shaw, W., et. al. Assessment of antifungal drug therapy in autism by measurement of suspected microbial metabolites in urine with GC/MS. Clinical Practice of Alternative Medicine: 15-26.
  5. https://alihealing.org/2018/10/02/what-might-autism-teach-about-alzheimers-disease-ad-what-might-ad-teach-about-autism/
  6. Ali M. Succinate Retention. In: Chouchani ET, Victoria R. Pell VR, Edoardo Gaude E, et. al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 2014;515:431–435.
  7. Ali M. Succinate Retention: The Core Krebs Dysfunction in Immune-Inflammatory Disorders. Townsend Letter. 2015;388:84-85.

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