Philosophy and Science of Holism in Healing


Majid Ali, M.D.

140 West End Avenue, New York, NY 10023

212-873-2444

344 Prospect Avenue, Hackensack, New Jersey 07610

201-996-0027

Majidalimd@aol.com


One Physician’s  61-Year Journey in Fields of Healing

First published in 2015 in APPNA Journal (2015;25:17-18)

(The Journal of the Association of Physicians of Pakistani Descent of North America)

https://majidalimd.me/2019/03/02/holism-in-healing-science-and-philosophy/


Philosophy and Science of Holism in Healing

Majid Ali, M.D.

APPNA 2015;25:17-18 

On June 20, 2015, a week before my 75th birthday, I received a precious and humbling gift. It was an e-mail from the editors of the journal Nature informing me of the concurrent publication (ref. 1)of my two sets of Krebs cycle data shown in the Table below, one collected before 2004 and the other between 2004 and 2015. In my 2004 report I presented evidence for respiratory-to-fermentation shift as the molecular basis of energy deficits in      immune-inflammatory and chronic energy disorders. I recognized succinate as the principle metabolite of concern in mitochondrial dysfunction. Validity of these observations was established in a seminal paper published in Nature in 2014 in which succinate retention was shown to be the principal Krebs cycle abnormalities (ref. 3).

Simply stated, the core clinical significance of my 2004 data was this: Restoration of all oxygen-driven mitochondrial function by effectively addressing all relevant nutritional, environmental, and spiritual elements must be considered as the primary goal in healing in all chronic diseases. The journal Nature specifically validated the part concerning my inference relating to immune-inflammatory disorders.

My Nature report marked the apex of a journey that started 61 years earlier when I joined King Edward Medical College, Lahore, Pakistan. An important milestone in this journey occurred in 1974 when I received my appointments as chief pathologist and laboratory director at Holy Name Medical Center, Teaneck, New Jersey, and as an adjunct associate professor in the Department of Pathology,  Columbia University, New York. It started with a simple question: what might be the boundary between the state of health and states of absence of health? I recognized that for the answer to the question, I needed to reach beyond microscopes and laboratory technology at my disposal in Teaneck and in New York.

In 1968, I received the diploma of the Fellow of Royal College of Surgeons, England. By then, the events surrounding my mother’s death twelve years earlier had receded. She was a Hafiz-e-Quran and suffered from pulmonary tuberculosis, which eventually claimed her life. She regularly asked me to listen to her recitations, looking for errors. Her cough often sprayed bloody sputum on my face. I was infected but never became sick. During years of surgical training, nothing was further from my mind than the questions of what might have primacy in a desert, the seed or the soil? Or in the human body, the microbe or the host? Or what might the states of bowel, blood, and liver ecosystems of my mother have had to do with her immunity and death from tuberculosis? Or the states of my ecosystems with my resistance to the bacillus?


Core Clinical Significance of Mitochondrial Dysfunction In Chronic Inflammatory and Energy Disorders

The data concerning mitochondrial dysfunction e-published in the journal Nature belonged to my non-selected patients with diverse chronic immune-inflammatory and degenerative disorders. One set was collected in years prior to 2004 and the second between 2004 and 2015 (second and third columns in the Table below).  I recognized that the clinical and demographic data provided me with a most extraordinary opportunity to examine mitochondrial function and/or dysfunction within the broader contexts of global mitochondrial dynamics in diverse chronic clinico-pathologic entities, rather than with a sharp focus on specific diseases in specific discrete age groups of patients. Follow-up data obtained after integrative intervention in many patients (not shown in the Table) then reflected patterns of restoration of mitochondrial function by effectively addressing all relevant nutritional, environmental, and spiritual elements must be considered as the primary goal in healing in all chronic diseases.

Table: The Frequency of Increased* Urinary Excretion of Krebs Cycle Metabolites In Chronic Inflammatory and Energy Disorders

Krebs Cycle Metabolite*

2004  Publication (n=236)

2015 Publication (n=315

Citric acid

194

315

Succinic Acid

40

55

Aconitic Acid

24

45

Fumaric Acid

2

2

2-Oxo-glutaric Acid

2

2

* Levels of acids measured in mmol/mol creatinine.


 

My Nature report (ref. 1) marked the apex of a journey that started 41 years earlier with a simple question: what might be the boundary between the state of health and states of absence of health? I recognized that for the answer to the question, I needed to reach beyond microscopes and laboratory technology at my disposal as the Director of the Department of Pathology and Laboratories at Holy Name Medical Center, Teaneck, New Jersey, as well as a faculty member at Columbia University, New York.

In 1968, I received the diploma of the Fellow of Royal College of Surgeons, England. By then, the events surrounding my mother’s death twelve years earlier had receded. She was a Hafiz-e-Quran and suffered from pulmonary tuberculosis. She regularly asked me to listen to her recitations, looking for errors. Her cough often sprayed bloody sputum on my face. I was infected but never became sick. During years of surgical training, nothing was further from my mind than the questions of what might have primacy in a desert, the seed or the soil? Or in the human body, the microbe or the host? Or what might the states of bowel, blood, and liver ecosystems of my mother have had to do with her immunity and death from tuberculosis? Or the states of my ecosystems with my resistance to the bacillus?

In 1983, I published a monograph entitled Spontaneity of Oxidation in Nature and Aging,(ref.7) in which I proposed my oxidative theory of aging. This spontaneity seemed to initiate and drive the redox dynamics in the body – the human equivalent of the Second Law of Thermodynamics, so to speak – and appeared to be a highly plausible primal mechanism for disease initiation and progression. Within this evolutionary context, in 1987 I summarized my observations and reflections concerning the gating functions of biomemebranes in a monograph entitled Oxidative Leaky Cell Membrane Disorder (ref. 8)

Human evolution occurred as trillions of energetic experiments – steps, mis- steps, and counter-step, inevitably constituting the pathways of molecular complementarity and contrariety. A study of the history of oxygen on planet Earth led to my recognition of oxygen as the king of human biology.

During the early 1980s, I recognized the crucial need for ecologic thinking in clinical medicine and published a monograph entitled Altered States of Bowel Ecology (ref. 8) to focus on the centrality of the bowel in all deliberations of health/dis-ease/disease continuum. In this volume, I described my seed-feed-and-weed guidelines for restoring bowel ecology disrupted by heavy sugar intake, frequent use of antibiotic abuse, neglect of mold and food allergy, and chronic stress.

In the early 1990s, I had my “oxygen eureka moment,” in which I saw two things clearly: (1) all chronic diseases were rooted in dysfunctional oxygen signaling; and (2) restoration of oxygen homeostasis was the true nature of healing from chronic disease. To date, I have not found scientific evidence to the contrary. Continued clinical, microscopic, and biochemical studies in this direction led to the development of my oxygen models of inflammation, autoimmunity, obesity, diabetes, cardiac myocytic disease, coronary artery disease, chronic renal failure, polycystic ovarian syndrome, and many other diseases. Full descriptions of these models and lines of evidence to support them are posted at http://www.aliscience.org.event in revascularization injury (ref. 3)

The oxygen models of diseases are unifying models that explain all aspects of the health/dis-ease/disease continuum—causes, clinical course, consequences, and control—on the basis of disturbed oxygen functions. The most important among them are: (1) impaired or blocked oxygen signaling; (2) interrupted oxygen’s ATP energy generation; (3) diminished oxygen’s detergent functions; (4) interrupted oxygen’s cellular detox functions; (5) impeded oxygen-governed cellular repair mechanisms; and (6) oxygen-regulated cell membrane and matrix functions. These abnormalities usually begin in the early years of life but may develop at any time.


 

What Is Disease?

In the early 1990s, I began to define disease in two ways:

  1. (A negative energetic-metabolic (respiratory-to-fermentative) shift (an energetic degradative shift from high-efficiency energetics of oxygen-driven metabolism to a low-efficiency fermentative metabolism); and
  2. (A spiritual shift to a state of separation from one’s nature.

Three Primary Mechanisms of Chronic Disease

  1. Dysfunctional oxygen signaling (Dysoxygenosis [dys –oxy–ge–nosis]

  2. Overactive insulin signaling

  3. Excessive Gut Fermentation 

The therapeutic approach to the first disease dimension required detection and management of all relevant threats to oxygen homeostasis with nutritional and environmental measures, while the second dimension required healing along one’s own pathways to one’s soul. In this broader context of “oxygen-based holism,” the prevailing focus on disease classifications based on microscopic patterns of chronic tissue injury then becomes of secondary importance.

I point out that 23 years after I published Altered States of Bowel Ecology, the journal Nature fully endorsed that position in a 2010 article with the following words: “By 2020, personalized health care could involve doctors monitoring the metabolic activities of a patient’s gut microbes and, possibly, modulating them therapeutically” (Nature 2010;463:32).

Next, consider the following words, again from journal Nature: “World Health Organization warns that world may be heading into a ‘post-antibiotics era’” Nature (2014;516:302).

One day, let us hope, the science and philosophy of holism in healing traditions will rise to yet a higher level – of the whole-body ecology – which looks at the body microbes as an integral part of the whole, which also needs to heal.

P.S. In closing, I wish to express my deepest gratitude to Nature editors for there sustained support for my contributions to the Discussion Section of the Journal in which I attempted to highlight the relevance and importance of many seminal Nature papers for integrative clinicians. We physicians face many clinical imperatives for which scientific rationale provided by such Nature articles often offer us hope when the sound scientific basis for our clinical decisions are not forthcoming.

References

  1. Ali M. Succinate Retention. http://www.nature.com/nature/journal/ v515/n7527/full/nature13909.html.
  2. Ali M. Respiratory-to-Fermentative (RTF) Shift in ATP Production in Chronic Energy Deficit States. Townsend Letter for Doctors and Patients. 2004. August/Sept. issue. 64-65.
  3. Chouchani ET, Victoria R. Pell VR, Edoardo Gaude E, et. al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature 515, 431–435.
  4. Ali M. The Principles and Practice of Integrative Medicine Volume X: Darwin, Oxygen Homeostasis, and Oxystatic Therapies. 3 rd. Edi. (2009) New York. Institute of Integrative Medicine Press.
  5. Ali M. The Principles and Practice of Integrative Medicine Volume XI: Darwin, Dysox, and Disease. 2000. 3rd. Edi. 2008. New York. (2009) Institute of Integrative Medicine Press.
  6. Ali M. The Principles and Practice of Integrative Medicine Volume XII: Darwin, Dysox, and Integrative Protocols. New York (2009). Institute of Integrative Medicine Press.
  7. Ali M. The Principles and Practice of Integrative Medicine Volume I: Nature’s Preoccupation With Complementarity and Contrariety. New York. Canary 21 Press. 1998. 2nd edition 2005.
  8. Ali M. Altered States of Bowel Ecology. (monograph). Teaneck, NJ, 1980.
  9. Ali M. Spontaneity of Oxidation in Nature and Aging, (monograph). Teaneck, NJ, 1983.
  10. Ali M. Leaky Cell Membrane Disorder (monograph). Teaneck, NJ, 1987.

P.S. Minor changes in the text originally  published in APPNA journal were made to clarify some aspects for this publication.


 

 

Dr. Ali’s Library of Molecular Biology of Oxygen

 

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  • Oxygen Models of Diseases

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  • Evidence of Oxygen Models of Diseases

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    Evidence of Oxygen Models of Diseases

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  • Oxygen Model of Pain

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  • Oxygen In Acid Out Part One

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  • Varicose Veins and Oxygen

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    Varicose Veins and Oxygen

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  • The Oxygen Model of Cancer 1 - Basics

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  • Hydrogen Peroxide Foot Soaks and Baths – AliHealing.org

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    This is a four video course and book – The Butterfly and Life Span Nutrition from Majid Ali, MD. Learn more only $25 This is a seven video course and book – Reversing Diabetes from Majid Ali, MD.

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  • Dr Ali Course on Cancer – aliacademy.org

    www.aliacademy.org/dr_ali_course_on_cancer.htm

    In this 40-minute video seminar, Professor Majid Ali, M.D. presents his Oxygen Model of Cancer and describes its crucial clinical significance. The core of this model is that a cancer cell is a fermenting cell. The Oxygen Model of Cancer is an extension of his Oxygen Model of Health and Disease.

  • Majid Ali

    www.aliacademy.org/index.html

    Seminar 6 – Oxygen Protocol for Treating Cancer Dr. Ali‘s Course on Cancer Seminar 8 – Cancer Killing Spices $34.95: Professor Majid Ali presents the physiology, pathology, and clinical features of responses to chronic stress. Three video bundle only $14.95 Dr. Ali‘s Stress Control Program Dr. Ali‘s Course on Stress

  • Oxygen and Aging, Second Edition [Majid Ali] on Amazon.com. *FREE* shipping on qualifying offers. New updated Second Edition of Oxygen and Aging by Majid Ali, M.D. Dr. Ali discusses how oxygenis the organizing influence of human biology and governs the aging process.

  • Oxygen Course – Majid Ali | Ali Academy

    aliscience.org/2017/12/01/oxygen-course-majidali

    Majid Ali, M.D. Oxygen for Health and Healing UNDERSTANDING OXYGEN TO UNDERSTAND HEALTH/DIS-EASE/DISEASE CONTINUUM — AND CONSCIOUSNESS Oxygen is the organizing influence of human biology and governs the aging process. It is the primary “energy-nutrient” molecule of human biology.

  • Professor Majid Ali shares information about “Cancer, Oxygen, and Otto Warburg”

  • Water for Oxygen | Majid Ali MD | The Ali Academy Community

    majidalimd.me/…/12/water-for-oxygenmajidali-md

    WATER FOR OXYGENMajid Ali, M.D. Health, at the basic level, is the oxygen rhythm of life. Next to slow limbic breathing, water is the simplest, safest and cheapest way of preserving that rhythm.

  • n this companion videos in the “Three Healing Sciences Series,” I make a crucial distinction between what I designate as “disease-drug sciences”… Majid Ali, M.D. – Healing Science of Oxygen on Vimeo

For general readers and students of this course without biology background, I especially recommend my book Oxygen and Aging (available by calling 212-873-244 0r 201-996-0027).

 

 

 

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