Diabetes Prevention and Reversal Course


Majid Ali, M.D.

Fellow of Royal College of Surgeons of England

Diplomate, American Board of Surgical Pathology

Diplomate, American Board of Clinical Pathology

Diplomate, American Board of Environmental Medicine

Diplomate, American Board of Chelation Therapy


140 West End Avenue, New York, NY 10023

212-873-2444

344 Prospect Avenue, Hackensack, NJ 07601

201-996-0027


 

Core Tragedy In Diabetes Prevention and Reversal

1. Is Diabetes a Sugar Problem?

2. Is Diabetes a Derangement of Insulin Homeostasis?

3. What Is Optimal Insulin Homeostasis?

The above three crucial question about diabetes have never been raised, nor examined, nor researched in the fields of endocrinology, cardiology, internal medicine, or family practice. Nor have three questions held any interest for practitioners, teachers, and researchers in the fields of obesity, dialysis, dementia, and stroke bariatrics. This is likely to surprise many readers. I ask them to simply Google the following simple sentence:  “What Is Insulin Homeostasis?”


Diabetes (the main T2D Hyperinsulinism Predates Diagnosis of Diabetes by Five, Ten, or More Years. During these years, insulin toxicity of hyperinsulinism remains undetected and unheeded, and continually injures nearly all cell populations in the body. Most notably, it enlarges liver with fatty deposits (fatty disease of the liver) and shrinks the brain  by  decreasing blood and oxygen supply to the brain.


Optimal Insulin Homeostasis

Optimal insulin homeostasis is the insulin profile during the day which shows the lowest blood concentrations of insulin associated with blood sugar levels in the physiological ranges. In most such insulin/blood sugar profiles obtained after a glucose challenge, the blood insulin concentrations representing the optimal insulin homeostasis are in the following ranges: 

Fasting Insulin Levels:                                                 2-5  uU/mL

Peak Insulin Levels in Women:                                 Less Than 20 uU/mL

Peak Insulin Levels in Men:                                       Less Than 25 uU/mL

Insulin Level at 3 Hours After Glucose Load:       Less than 5 uU/mL


 

Laboratory tests for blood sugar levels are inappropriate for assessing optimal insulin homeostasis. 

 

 


Seminars Included in Diabetes Prevented, Diabetes Reversed Course

Seminar One   —  Introduction — Four Questions: (1) Who Profits from diabetes prevented, diabetes reversed? (2) Who Profits from diabetes treated? 

Seminar Two — Optimal Insulin Homeostasis. Diabetes Is Not a Sugar Problem

Seminar Three — Insulin Is a Life Span Hormone. 

Seminar Four — Neglected and Improper Insulin Testing Illuminated by Insulin Profiles of Ten Subjects

Seminar Five — Toxicity of Undetected Hyperinsulinism

Seminar Six —  What Is Gestational Diabetes? What Are Its                                                       Consequences

Seminar Seven  —  Insulin Diet for Diabetes Prevention and Reversal

Seminar Eight   —   Complications of Diabetes

Seminar Nine          —    Insulin-Toxic Liver Disease 

Seminar Ten    — Diabetes Delineates Pathways to Dialysis, and Dementia

Seminar Eleven    —    Dr. Ali’s Breakfast

Seminar Twelve   —- Insulin-Wise and Insulin-Unwise Foods

Seminar Thirteen —  Liver and Bowel Detox for Reversing Diabetes

Seminar Fourteen — The Brain Detox Dimension


Neglected and Improper Insulin Testing

The most disappointing aspect of the matter of insulin homeostasis in clinical practice is that, with very uncommon exceptions, hyperinsulinism is not detected with direct insulin testing. Insulin toxicity is allowed to inflict widespread cellular damage for years, sometimes for decades, until glycemic criteria for the diagnosis of Type 2 diabetes are met. This has been amply documented in this and past communications on the subject.

Below are some specific issues concerning improper insulin testing;

  1. Insulin tests are performed on randomly drawn blood tests (Results of such tests  cannot be interpreted with confidence);

  2. Laboratories employ utterly unusable references ranges for blood insulin concentrations, as documented definitively in Table 1;

  3. Tests for glycemic status (fasting blood  glucose, two-hour postprandial glucose level, A1c levels) are performed as substitutes indicators of the insulin status;

  4. Cut-off points for post-glucose challenge blood insulin concentrations reported in laboratory reports are not based on actual post-glucose-challenge testing data; 39

  5. Gestational diabetes is a hyperinsulinism disorder before it becomes gestational diabetes by glycemic criteria;

  6. Pregnant women are unscientifically and improperly assured of their metabolic health simply because their glucose tolerance tests are considered negative for gestational diabetes;

  7. Insulin is the primary pro-weight gain and pro-obesity hormone, and yet insulin tests are not done in weight loss and obesity programs.

  8. Failure to assess insulin homeostasis with direct post-glucose challenge tests leaves patients and clinicians in the dark concerning the central roles of hyperinsulinism in the pathobiology of   chronic inflammatory, infectious, autoimmune, metabolic, neoplastic, and degenerative disorders.

Two important concerns in this context are: (1) Study of Responses to Carbohydrates and Non-carbohydrate Challenges In Insulin-Based Care of hyperinsulinism and related Metabolic Disorders40; and (2) Importance of Subtyping Diabetes Type 2 Into Diabetes Type 2A and Diabetes Type 2B.41

It is lamentable that in the dominant medical thought, crucial health and healing aspects of chronically sluggish oxygen signaling and incrementally exaggerated insulin signaling are consistently neglected. How often is the centrality of dysoxygenosis (dysfunctional oxygen signaling) in chronic diseases recognized and effectively addressed in doctors’ offices and clinics? How often are the fattening, fermenting, and inflaming effects of simmering hyperinsulinism detected and controlled by restoring optimal insulin metabolism? Mention of mitochondrial malfunctions evokes tired yawns; the word insulin triggers Pavlovian mumbling about diabetes.


 

Seven Stages of Insulin Toxicity

In matters of the life span, I summarize the lessons learned from my patients with the following simple words:

*  Keep insulin low without drugs and live longer, or

*  keep blood sugar low with drugs and die young.

The pandemic of diabetes can be neither understood nor addressed without knowing the fundamentals of the molecular biology of insulin, a subject that is sadly and regularly neglected in the prevailing model of medicine. I wrote Insulin Toxicity Series to shed lights on the various faces of this pandemic.


My patients also helped me recognize seven stages of insulin toxicity:

.  The first stage of insulin toxicity is without apparent negative health effects recognized by the person.

.  The second stage of insulin toxicity is with negative health effects recognized by the person but unknown to the doctor.

.  The third stage of insulin toxicity is tissue injury (in the liver, kidneys, skin, and other organs) unrecognized by a doctor who is clueless about molecular biology of insulin.

.  The fourth stage of insulin toxicity is prediabetes without tests to detect insulin waste and damages.

.  The fifth stage of insulin toxicity is Type 2 diabetes with the use of diabetes drugs (that add to the insulin activity, hence its toxicity) (with the blessings of the American Diabetic Association).

.  The sixth stage of insulin toxicity is toxicity created by peaks of insulin caused by insulin injections (the end-stage of insulin depletion which is called insulin-dependent diabetes).

.  The seventh stage of insulin toxicity is loss of vision and blindness (diabetic retinopathy), dialysis (diabetic nephropathy), and increased risk of heart attacks, strokes, autoimmune diseases, inflammatory disorders, and all degenerative states.

I present evidence for all of the above in other 29 parts articles in my Insulin Toxicity Series:

The Take-home Message

of this article is: the use of diabetes drugs to lower blood sugar levels without non-drug plans to lower blood insulin levels to lower insulin levels is feeding pandemic of insulin toxicity and diabetes. The American Diabetic Association and The New England Journal of Medicine teach doctors to use only drugs to lower blood sugar when what the people really need are programs to de-grease the cell membranes, free up insulin receptor proteins embedded in the membranes, and lower blood insulin levels.


s:

*  Keep insulin low without drugs and live longer, or

*  keep blood sugar low with drugs and die young.

The pandemic of diabetes can be neither understood nor addressed without knowing the fundamentals of the molecular biology of insulin, a subject that is sadly and regularly neglected in the prevailing model of medicine. I wrote Insulin Toxicity Series to shed lights on the various faces of this pandemic.


My patients also helped me recognize seven stages of insulin toxicity:

.  The first stage of insulin toxicity is without apparent negative health effects recognized by the person.

.  The second stage of insulin toxicity is with negative health effects recognized by the person but unknown to the doctor.

.  The third stage of insulin toxicity is tissue injury (in the liver, kidneys, skin, and other organs) unrecognized by a doctor who is clueless about molecular biology of insulin.

.  The fourth stage of insulin toxicity is prediabetes without tests to detect insulin waste and damages.

.  The fifth stage of insulin toxicity is Type 2 diabetes with the use of diabetes drugs (that add to the insulin activity, hence its toxicity) (with the blessings of the American Diabetic Association).

.  The sixth stage of insulin toxicity is toxicity created by peaks of insulin caused by insulin injections (the end-stage of insulin depletion which is called insulin-dependent diabetes).

.  The seventh stage of insulin toxicity is loss of vision and blindness (diabetic retinopathy), dialysis (diabetic nephropathy), and increased risk of heart attacks, strokes, autoimmune diseases, inflammatory disorders, and all degenerative states.

I present evidence for all of the above in other 29 parts articles in my Insulin Toxicity Series:


The Take-home Message

of this article is: the use of diabetes drugs to lower blood sugar levels without non-drug plans to lower blood insulin levels to lower insulin levels is feeding pandemic of insulin toxicity and diabetes. The American Diabetic Association and The New England Journal of Medicine teach doctors to use only drugs to lower blood sugar when what the people really need are programs to de-grease the cell membranes, free up insulin receptor proteins embedded in the membranes, and lower blood insulin levels.


    • Majid Ali MD, Insulin Health and Free Insulin Course

      3:27
      Majid Ali MD, Insulin Health and Free Insulin Course

      vimeo.com

    • Majid Ali MD, Insulin Buddy - Who Should Become?

      5:38
      Majid Ali MD, Insulin Buddy – Who Should Become?

      vimeo.com

    • Majid Ali MD, Insulin Buddy and Fatty Liver

      4:23
      Majid Ali MD, Insulin Buddy and Fatty Liver

      vimeo.com

    • Insulin-Creatinine Testing Majid Ali, MD

      7:27
      Insulin-Creatinine Testing Majid Ali, MD

      vimeo.com

  1. Insulin-toxicity – Majid Ali

    www.aliacademy.org/fatty-liver-2.htm

    Majid Ali, M.D. Reversal With Insulin-Reducing Diet and Detox Program Fatty liver is an unrecognized epidemic affecting all age groups. It is caused by the trio of toxicities of foods, environment, and thoughts.

  2. Insulin-Sugar Choice – Insulin Institute

    www.insulininstitute.org/insulin-sugar_choice.htm

    The Insulin-Sugar Choice. Majid Ali, M.D. We have choices. We can keep insulin low and live longer, or keep insulin high and die young. We can focus on lowering blood sugar and die young, or focus on lowering blood insulin level and live longer.

  3. Insulin Toxicity | Ali Academy

    aliscience.org/category/insulin-toxicity

    Majid Ali, M.D. The simple answer: All persons with Type 2 diabetes suffer from excess insulin and insulin toxicity, and all diabetes drugs increase the degrees of insulin toxicity. Excess insulin is acidifying, “free-radicalizing,” inflaming, and increases the buildup of grease in fat cells.

  4. WIKI-MEDICAL – drali1.org

    drali1.org/insulin_seven_stages.htm

    Seven Stages of Insulin Toxicity. Majid Ali, M.D. In matters of the life span, I summarize the lessons learned from my patients with the following simple word * Keep insulin low without drugs and live longer, or * keep blood sugar low with drugs and die young.

 

 


 

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s