Metabolic reprogramming by Nitric Oxide and Oxidative Therapeutics

Majid Ali, M.D.

140 West End Avenue, New York, NY 10023



Important Aspects

1.Clinical uses

2.Empirical benefits. (cite dialysis paper)

3. Most energy-generating systems are initiated and perpetuated by oxidants, not by antioxidants. Gas pedals, brake pedals.




  1. Zhou H-L, Zhang R, Ananad P, et al. Nature. 201Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury. Nature. 2019;565:96-100.
  2. Wang, W. et al. Endothelial nitric oxide synthase-deficient mice exhibit increased susceptibility to endotoxin-induced acute renal failure.  J. Physiol. Renal Physiol287, F1044–F1048 (2004)
  3. Forbes, M. S., Thornhill, B. A., Park, M. H. & Chevalier, R. L. Lack of endothelial nitric-oxide synthase leads to progressive focal renal injury.  J. Pathol. 2007;170, 87–99.
  4. Gabbay, K. H. et al. Ascorbate synthesis pathway: dual role of ascorbate in bone homeostasis.  Biol. Chem. 2010;285, 19510–19520.
  5. Anastasiou, D. et al. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. 2011. 334, 1278–1283 (201




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