Adrenal Fatigue

I care for people with adrenal dysfunction. I do not treat adrenal diseases


Deaths associated with adrenal crisis occurred in approximately 6% of cases, emphasizing the need for improved management of the life-threatening complication in patients with chronic adrenal insufficiency, German researchers wrote.

“Using for the first time a prospective approach, our study provides unequivocal evidence of a high incidence of [adrenal crisis] in patients with chronic adrenal insufficiency receiving standard replacement therapy,” the researchers wrote.

Creating Conditions for Adrenal Regeneration

(1) all chronically ill people have adrenal dysfunction

(2) the adrenals regenerate in most cases when all relevant oxygen-related elements are addressed

(3) short-term adrenal support (supplementation) is often necessary for months, sometimes for longer periods, during adrenal recovery.

Ten Important Considerations

There are ten important considerations concerning adrenal dysfunction.

1. The existence of adrenal dysfunction can be easily established with simple urine tests.

2. The adrenal dysfunction of every individual requires individualized integrative plan for regeneration and recovery.

3. The essential “adrenal question” is not what diagnostic label is chosen for a person with a dysfunctional gland—people everywhere are diminished by contaminated foods, habitat chemicalization, and unrelenting stress—but how their adrenal function can be assessed and restored.

4. The degrees of adrenal dysfunction are best assessed clinically, as well as with the measurement of 24-hour urinary excretion of adrenal and gonadal metabolites.

5. Adrenal regeneration requires spiritual equilibrium and full restoration of oxygen homeostasis.

6. All disruptions of the bowel, blood, and liver ecosystems must be effectively addressed for adrenal homeostasis.

7. In my clinical experience, the direct short-term adrenal support is optimally provided with hydrocortisone, beginning with small doses of 2.5 mg twice daily to larger doses of 10 to 20 mg daily.

8. The inter-relationships of the adrenal gland with stress, the hypothalamic-pituitary axis (HPA), gonadal output, insulin metabolism, and the energy economy cannot be understood without except by looking through the prism of oxygen homeostasis.

9. Most people with adrenal dysfunction pass from an initial overactive (hyperadrenergic or Cushing’s syndrome-like state) to a later underactive (hypoadrenergic, Addison’s disease-like) state.

10. An increasing number of young people are “gender-skewed”—females are “male-like” and males are “female-like,”so to speak—and the adrenals play crucial roles in the phenomenon of gender devolution.

The Adrenal Gland Is Oxygen’s Crisis Manager

The Oxygen King of human biology evolved the adrenal gland to serve as its primary crisis manager. Oxygen preserves the structural and functional integrity of adrenals in many ways. When adrenals falter, oxygen strengthens them by evoking homeostatic responses in other regulatory systems of the body. When the glands are exhausted, oxygen regenerates them. When the Oxygen King is besieged by toxic overloads and is unable to create conditions for adrenal regeneration, the glands fail, collapsing the entire crisis management functions of the body.

Thyroid-Tired or Adrenal fatigued Majid Ali MD

When survival is threatened, oxygen mounts a “total-body response” for maximal effort to counter the threat. Oxygen directs the adrenal glands to release bursts of catecholamines to support the highest level of preparedness throughout the body. Catecholamines—epinephrine, norepinephrine, dopa, and others—are some of the most potent oxidizers in human biology and energize host defenses of all cell populations. Below are the aspects of oxyradical dynamics that support my evolutionary perspective of the oxygen-driven adrenal differentiation and function.

Adrenal Supplementation for Adrenal Regeneration

I care for people with adrenal dysfunction. I do not treat adrenal diseases. The cases of benign adrenal tumors and adrenal cancers, of course, are different. I have addressed the crucial issues of philosophic and spiritual equilibrium and the restoration of the bowel, blood, and liver ecosystems in past articles. As for providing adrenal support until there is sufficient adrenal regeneration, there are two approaches:

(1) direct support with hydrocortisone

(2) indirect support with raw adrenal extract, phytofactors (plant remedies), and nutrients.

Below, I relate how I concluded that direct adrenal support yields superior clinical results in most cases. In the mid-1980s, I investigated the clinical benefits of bovine raw adrenal concentrate, as well as phytofactors and nutrients for adrenal support.

Among the phytofactors, prescribed in combinati[ons and rotations, were daily doses of:

  • roots of licorice (DGL form 500 to 1,000 mg),
  • rehmannia (500 to 750 mg),
  • ashwargandha (100 to 200 mg), and
  • Chinese yam (500 to 750 mg).

Among the nutrients were daily doses of

  • pantothenic acid (50 to 150 mg),
  • pyridoxin (25 to 50 mg),
  • riboflavin (10 to 20 mg), and
  • ascorbic acid (1,000 to 2,000 mg).

These adrenal factors were prescribed concurrently with antioxidants, minerals, and redox-restorative substances, such as glutathione, MSM, taurine, and others.

Precious Trio of Enzymes for Health – Catalase, Superoxide Dismutase , & Glutathione Majid Ali MD from Majid Ali on Vimeo.

I urge readers to consult an experienced integrative physician to guide them for adrenal regeneration and healing.

Simple understandings of Oxygen and Adrenal Dysfunctions

The Oxygen Model of Disease is a unifying model of enormous explanatory power—for understanding the basic nature of the disease processes, as well as for designing testable, rational, and scientifically sound integrative plans for restoring health. My Oxygen Model of Adrenal Dysfunctions is at significant variance from the current thinking in endocrinology. Endocrinologists, with rare exception, continue to be preoccupied with named adrenal syndrome—Cushing’s syndrome, Addison’s disease, Conn’s syndrome, and Sheehan’s syndrome—as well as pituitary tumors and hypothalamic disorders. Such lesions account for an exceedingly small number of chronically ill individuals with objectively and quantifiably detected adrenal dysfunction. This, indeed, is one of the core messages of this article. My assertions are based on extended clinical work with over 7,500 patients with chronic illness and on close analysis of over 900 profiles of the 24-hour urinary excretion of steroid compounds.

Oxygen Models of Diseases from Majid Ali on Vimeo.

Oxygen’s Three-Legged Throne from Majid Ali on Vimeo.

Please consider these extended video courses

Dr. Ali’s Course On Healing Seminar 9 – Oxygen Model of Health and Disease
This seminar is the first of eight in Dr. Ali’s Course On Healing, Intermediate. Professor Majid Ali presents his Oxygen Mode of Health and Disease and Oxygen Model of  Disease. He speaks about his journey of a surgeon-turned-pathologist-turned-immunologist-turned-nutritionist-turned-ecologist-turned-“energy physician.” His unifying oxygen models are based on his evolutionary perspective of health, disease, and healing. His crucial issue is the promotion of what calls “Healing-Literacy” and shift of focus away from “Disease-Literacy” in matters of health and healing.

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Professor Majid Ali presents the physiology, pathology, and clinical features of responses to chronic stress.
All FOUR video bundle only $24.95
Order SINGLE VIDEOS Stress Support Protocols
Course on Stress Seminar 1
In this 45-minute seminar, Professor Majid Ali, M.D. explains that the prevailing “flight or fight” notion of stress is so inadequate that it is not clinically useful. Fermentation in the bowel, stomach, and mind (frustration, anger and deep disappointments) play greater roles than the adrenal overdrive and depletion. In seminar 2, Prof. Ali offers his preferred natural remedies for controlling and preventing stress.

Course on Stress -Seminar 2 – Stress Control Program
In this 40-minute seminar 2 of “Dr. Ali’s Course on Stress Control and Prevention, Professor Majid Ali, M.D. offers his preferred natural remedies for controlling and preventing stress. In seminar 1 of this series, he explained that except in uncommon cases, chronic stress begins with fermentation in the bowel, stomach, and liver, and then leads to fermentation in the mind (chronic frustration, deep disappointments, anger, and rage). In this seminar he offers his guidelines for addressing these problems. His main suggestions are: (1) Living a spontaneous life; (2) knowing the difference between “Beware Living” and “Be-Aware Living” (3) Dr. Al’s 7: Breathing; (4) Dr. Ali’s Breakfast; (5) Dr. Ali’s Glutamine-White Poppy Seed Protocol” (6) Direct oxygen therapies (and herbs for the brain).
Course on Stress -Seminar 3 – The Be-Aware Living
In this 35-minute seminar 3 of “Dr. Ali’s Course on Stress Control and Prevention, Professor Majid Ali, M.D. focuses on what he calles “The Be-Aware Way.” He points out the difference between “The Beware Living” and “The Be-Aware Living.” The latter is a life of a script delineated by someone else while the former is script of life defined by the individual. He reflects on the subjects of spirituality, morality, Divinity, and self-compassion in the context of stress and anxiety.

Course on Stress – Seminar 4 – Science of Be-Aware Living
This 40-minute seminar 4 of “Dr. Ali’s Course on Stress” presents the science of “Be-Aware Living”. Professor Ali defines “Be-Aware Living” as a life of one’s own script to contrast it with what he calls “Beware Living,” which is life lived by somebody else’s life script. He considers this as the core of his approach to the problem of stress.


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