A Free Course on Nutrition | Sugar Shortens Life
A Free Course on Nutrition | Sugar Shortens Life
Majid Ali, M.D.
Excess sugar is inflaming, fattening, and oxygen-depleting—and, as a consequence, life- shortening. I delineated these relationships in Oxygen and Aging (2000).2
- Briefly, excess sugar builds grease on cells membranes, and suffocates them when the grease is not expediently removed by the body’s detergent system.
- Suffocated cells cannot breathe and rapidly bloat with acids and internal grease on mitochondria and other crucial cell innards.
- The end result of all this is a decrease in the supply of oxygen and impairment of its functions.
- Of course, rancid fats, mangled proteins, cellular waste and metabolic debris add to the cellular grease. This is the basic nature of the “oxygen-sugar-shortened-life connection.”
- These phenomena are described and illustrated at length in my book on Diabetes.3
Direct evidence for my view has been established in experimental studies. For example, in one series of experiments, the life span of a common form of yeast increased by 25% when the glucose level in the culture is reduced from 2% to 0.5%.3
More important, recently Professor Cynthia Kenyon and colleagues at the University of California showed that glucose shortens the lifespan of C. elegans round worm.4
Next to oxygen, insulin is the most metabolic Dr. Jekyll/Mr. Hyde in the body. In its narrow healthful range, the Dr. Jekyll is pro-health, anti-diabetes, anti-immune, anti-degenerative, anti- hypertensive, anti-stroke, anti-heart attack, and anti-premature aging. When in excess, the Mr. Hyde is anti-health, pro-diabetes, pro-immune, pro-degenerative, pro-hypertensive, pro-stroke, pro-heart attack, and pro-premature aging. A clear comprehension of these Dr. Jekyll/Mr. Hyde roles of insulin is essential for understanding the Oxygen-sugar-shortened-life-connection which I present here. I present this subject at length in several companion articles on this website.
Theories of Oxygen and the Oxygen-sugar-shortened-life Connection
Below is text adapted from my earlier writings to shed light on the oxygen-sugar-shortened- life connection and its clinical significance.
During 1930s, Clive McKay established that caloric restriction extends life span in many species.5 He implied that is the only way of increasing the lifespan of mammals. Since that classic work, an enormous body of literature has accumulated validating the direct relationship between caloric restriction and longevity.6-11 This linkage has been documented in yeast, mosquitoes, flies, and rats. Since glucose is the primary energetic currency of human metabolism and fats and proteins in the body are converted to glucose when needed, it would be expected that less food intake means less glucose. In a larger sense, McKay’s work established the basic tenets of the oxygen-sugar- shortened-life connection.
In 1983, I put forth my Spontaneity of Oxidation Model of Aging.12 This model holds that aging involves loss of energy triggered, perpetuated, and completed by the ongoing and spontaneous loss of electrons in the body. Even a cursory look at the cross-linkage, free radical, and immune theories makes it clear that the Spontaneity of Oxidation Model is fully consistent with all three. Indeed, my model then represented an extension of those theories in the sense that it provided a clear underlying mechanism for all three.
In 1996, Professor Cynthia Kenyon and colleagues at the University of California showed that the lifespan of C. elegans round worm can be extended by removing one copy of a “stop the clock” (daf-2) gene.13-15 They concluded that the program, which controls longevity in the worm, can be uncoupled from other physiological processes. In that year, Guy Ruvkun demonstrated that daf-2 and age-1 genes were part of the same genetic pathway, and that daf-2 encodes an insulin receptor, thus linking aging to insulin signaling.16-17
During the late 1990s, Leonard Guarente and David Sinclair showed that the lifespan of yeast can be extended when its DNA is stabilized (rearrangements are prevented).18-20 Specifically, the yeast live about one-third longer when an extra copy of Sir2 gene is inserted in it to stabilize its DNA. The Sir2 gene is considered to be the founding member of the family of genes that encode sirtuins, proteins that evolved about a billion years ago to preserve the life span of various species during periods of stress.
The Oxygen Model of Aging
In Oxygen and Aging (2000), I proposed my unifying Oxygen Model of Aging.21 This model integrates all known aspects of the the aging process. Models in medicine are proposed for two primary reasons: (1) for their power to bring together seemingly disparate findings to make a meaningful whole; and (2) to provide scientific rationale and/or basis for designing strategies for meaningful interventions. The dysox model of aging has enormous explanatory power for nearly all, if not all, clinical, epidemiologic, and experimental observations concerning the aging processes in humans as well animal aging models.
As for designing intelligent interventional strategies, the Oxygen Model of Aging shifts the focus from the dynamics of individual genes to a holistic view of the three primary regulatory mechanisms of the body: oxygen homeostasis, redox equilibrium, and acid-base balance. For addressing those issues, I employ the Sun-Soil Model of the health/dis-ease/disease continuum. The Sun in that model symbolizes a person’s spiritual belief in the healing dynamics, whereas the soil is represented by ecologic dynamics and inter-relationships among the bowel, blood, and liver ecosystems. The Sun-Soil Model of health and healing has been described at length in Darwin and Dysox Triology, the tenth, eleventh, and twelfth volumes of The Principles and Practice of Integrative Medicine (2009).
In closing, I offer comments on another aspect of the sugar problem. The dangers of sugar are not duly recognized by influential medical journals. In some cases, there is outright deception. To cite one example, below is text from a review article on ADHD published in The New England Journal of Medicine on January 13, 200521:
…interventions in the treatment of ADHD. Diets, including those involving the reduced consumption of sugar, were studied and found to affect behavior in no more than 1 percent of children.
Sugar found to affect behavior in no more than 1 percent of children with ADHD! The Journal might well have stated that ADHD affects only one of 1,000 American children. Both lies would be of the same magnitude.
The writer of the article never practiced nutritional medicine. Nor did the authors of the three articles he cites to support his assertion. They limit their work with children with ADHD to prescriptions of various drugs, as well as to suppressing the field of clinical nutrition.
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Healing Seminar 1 – Introduction
Life is growing and growing is learning. In his course, he offers simple and low-cost natural remedies to preserve health and reverse chronic disease.
Healing Seminar 2 – Cellular Fermentation Forms the Foundation of Disease
Professor Ali defines disease in two ways: (1) disease is a state of separation from one’s nature; and (2) disease is evolution in reverse. In this second of 8 seminars of “Dr. Ali’s Course on Healing,” he explains what he means by evolution in reverse.
Healing Seminar 3 – Oxygen Model of Inflammation
Professor Majid Ali recognizes and describes two modes of inflammation: (1) healing physiologic inflammation and (2) disease-causing pathologic inflammation. He explains how no healing is possible without inflammation and how there is no disease in which inflammation does not play a crucial role.
Healing Seminar 4 – Breakfast Shake
In this 45-minute video seminar, Professor Majid Ali, M.D. presents his own breakfast taken four to five days a week. It consists of organic 12 ounces of vegetable juice and water, two tablespoons each of a protein powder and freshly ground flaxseed, one-and-half tablespoon of lecithin, and 12 ounces of water.
Healing Seminar 5 – Top Seven Natural Remedies
Professor Ali describes his top seven natural healing remedies as follows: (1) Limbic Breathing ; (2) Dr. Ali’s Breakfast; (3) Exercise; (4) Bowel-Liver Detox; (5) Castor Oil Rub Therapies; (6) Peroxide Oxygen Therapies; and (7) Ethical-Spiritual-Energy healing. He found these therapies to be safe and highly effective for all chronic disorders.
Healing Seminar 6 Natural Anti-inflammatory Remedies
In this 45-minute video seminar, Professor Majid Ali, M.D. presents his choices of most effective natural remedies for various inflammatory disease and how most people can avoid drugs for diseases, such as asthma, eczema, acne, psoriasis, arthritis, trigger points, fibromyalgia, lupus, interstitial cystitis, polymyalgia, sarcoidosis, Crohn’s colitis, ulcerative colitis, and others.
Healing Seminar 7 – Bowel Detox –
In this DVD video seminar, Prof. Ali describes his guidelines for gentle daily bowel detox and colon cleanse. He explains the advantages of this approach over intense one-week to 3-week programs which, notwithstanding their temporary benefits, often create adverse effects programs bowel.
Healing Seminar 8 – Liver Detox
In this DVD video seminar, Prof. Ali describes his guidelines for gentle daily liver detox. He explains the advantages of this approach over intense one-week to 3-week programs which, notwithstanding their temporary benefits, often create adverse effects. The guardian angel of the liver is the bowel. Please view Dr. Ali’s Bowel Video Detox Seminar for a deeper understanding of this subject.
Healing Seminar 9 – Oxygen Model of Health and Disease
Professor Majid Ali presents his Oxygen Mode of Health and Disease and Oxygen Model of Disease. He speaks about his journey of a surgeon-turned-pathologist-turned-immunologist-turned-nutritionist-turned-ecologist-turned-“energy physician.” His unifying oxygen models are based on his evolutionary perspective of health, disease, and healing.
Healing Seminar 10 – Acid-Alkali Balance
Professor Majid Ali explains the importance of acid-alkali balance in health preservation and the reversal of chronic disease. In his evolutionary perspective, he recognizes oxygen as the ultimate regulator of this balance. He cautions against too much reliance on the values of pH (acidity indicator) in blood, urine, and saliva samples, since these samples reflect the body’s responses to threats to the balance.
Healing Seminar 11 – Oxidant – Antioxidant Regulation
Professor Majid Ali presents the scientific facts of oxidant-antioxidant regulation, beginning with definitions of terms and simple explanation of natural processes called oxidation (loss of electron energy) and reduction (gain of electron energy) with simple analogies. Next he shows how oxygen regulates oxidant-oxidates reactions and why oxidant therapies are more important than antioxidant therapies.
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4. Lee S-J, Murphy CT, Kenyon C. Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression. Cell Metabolism, 2009; 5, 379-391.
5. McKay CM. Chemical Aspects of Aging and the Effect of Diet upon Aging. In: Cowdry’s Problems of Ageing. 3rd ed. 1952. Eds. AI Lansing. New York. Williams and Williams. p139.
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12. Ali M. Spontaneity of Oxidation in Nature and Aging. Monograph. 1983. Teaneck, New Jersey.
13. Kenyon C. Ponce d’elegans: genetic quest for the fountain of youth. Cell. 1996;84:501-504.
14.. Kenyon C. The nematode Caenorhabditis elegans. Science. 1988;240:1448-1453.
15. McCarroll, S. A., Murphy, C. T., Zou, S., Pletcher, S. D., Jan, Y. N., Kenyon, C., Bargmann, C. I., and Li, H. “Comparative functional genomics: Shared transcriptional program of adult maturation and aging in C. elegans and Drosophila.” Nature Genetics. 2004;36: 197-204.
16. Kimura KD, Tissenbaum HA, Liuv Y, Ruvkun G. (1997) daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 1997; 15:942-946.
17. Morris JZ, Tissenbaum HA, Ruvkun G. (1996) A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature (London) 382,536-539.
18. Guarente L. Sir2 links chromatin silencing, metabolism, and aging. Genes Dev. 2000;14:1021-1026.
19. Lamming DW, Wood JG, Sinclair DA. Small molecules that regulate lifespan: evidence for xenohormesis. Mol Microbiol. 2004;53:1003-9
20. Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature. 2001;410:227-230.
21. Rappley MD. Attention Deficit-Hyperactivity Disorder. N Eng J Med. 2005;352:165.