Women, Testosterone, disrupted chemical reactions

Women’s Testosterone Toxicity Syndrome

Majid Ali, M.D.

New research: Doctors are evaluating the association between testosterone and free testosterone and metabolic disturbances (disrupted chemical/hormone reactions) in polycystic ovary syndrome.

In brief they found Polycystic ovary syndrome women with elevated free testosterone levels have an adverse metabolic profile readings including 2 hour glucose, HbA1c, fasting and 2 hour insulin.1

In this article I introduce the term “Women’s Testosterone Toxicity State (WTTS) to sharply focus on what I see to an epidemic of testosterone toxicity in girls and women of all ages. With increasing frequency I see testosterone toxicity in girls and young women after they have seen pediatricians, gynecologists, and endocrinologists. Amazingly, when I review their records, I do not find the results of blood testosterone and insulin tests, the two tests that tell the whole story. Years later, such girls and women are diagnosed with polycystic ovary syndrome (PCOS).

Womens’ Testosterone Toxicity Syndrome (WTTS) Majid Ali MD from Majid Ali on Vimeo.

Polycystic Ovarian Syndrome Is Not An Ovarian Disease Majid Ali MD from Majid Ali on Vimeo.

Cystless Polycystic Ovary Syndrome

Sometime ago, I introduced the term “Cystless PCOS (Polycystic Ovary Syndrome Without Cysts) to underscore the essential metabolic toxicity nature of the problem. Below is some text from that article: “There is a disturbing rise in the incidence of insulin toxicity associated with hormonal and metabolic derangements in young girls and women. Equally disturbing is how often such cases are grossly mismanaged by their pediatricians and gynecologists.

Ladies of All Ages, Please Watch Out for Rising Blood Insulin and Testosterone Levels Majid Ali MD from Majid Ali on Vimeo.

To address these problems, in this article, I introduce the term “Cystless PCOS (Polycystic Ovary Syndrome Without Cysts).” With this term I want to underscore the importance of early recognition of a symptom-complex caused by insulin toxicity and excess testosterone and unaccompanied by bilateral ovarian cysts. The clinical features of Pre-PCOS include facial and chest hair, acne, menstrual abnormalities, loss of menstruation, weight gain, fatigue, and problems of mood, memory, and mentation. All my patients with Cystless PCOS had allergy and recurrent upper respiratory infections for which they received multiple courses of antibiotics. Some of them also suffered from asthma and had received multiple courses of steroids. ”

Facial Hair in Polycystic Ovary Syndrome from Majid Ali on Vimeo.

“The importance of recognizing this as a specific condition is that the failure to detect ovarian cysts on pelvic ultrasound does not lead to inadequate diagnostic testing (missed detection of insulin toxicity) and neglect of the crucial hormonal and metabolic derangements. Recently, The England Journal of Medicine recommended the use of Metformin (which not only ignores the real issue of insulin toxicity but actually worsens the problem in the long run).”

Polycystic Ovarian Syndrome – Why Don’t I Recommend Metformin for it Majid Ali MD from Majid Ali on Vimeo.

1. Lerchbaum E, Schwetz V, Rabe T, Giuliani A, Obermayer-Pietsch B. Hyperandrogenemia in polycystic ovary syndrome: exploration of the role of free testosterone and androstenedione in metabolic phenotype. PLoS One. 2014 Oct 13;9(10):e108263. doi: 10.1371/journal.pone.0108263. eCollection 2014.


The premium videos below are priced at $9.95 each

Female Testosterone Toxicity Syndrome Part One Seminar

Female Testosterone Toxicity Syndrome (FTTS) Seminar Part Two

Hormones – Dr. Ali’s Course on Hormones Seminar 1 – Estrogens, Progesterones, and Testosterone Are Health Hormones
Hormones – Dr. Ali’s Course on Hormone Seminar 2 – Estrogens and Progresterones Working Together
Hormones – Dr. Ali’s Course on Hormone Seminar 3 – Gender Devolution
Hormones – Dr. Ali’s Course on Hormone Seminar 4 – Precocious Puberty
Hormones – Dr. Ali’s Course on Hormone Seminar 5 – Menstrual Disorders
Hormones – Dr. Ali’s Course on Hormone Seminar 6 – Polycystic Ovarian Syndrome (PCOS)
Hormones – Dr. Ali’s Course on Hormone Seminar 7 – Receptor Restoration Before HRT

One comment

  • Dear Dr. Ali,

    Thank you for another of your wonderful, and unique view portraits of a syndrome. You always give a larger and more comprehensive picture of what is going on in the body and this is always enlightening. It is thanks to you that I have developed a more global view of the human biochemistry after nearly thirty years of reading all comers. Yours is the most complete view, and is vital to a good comprehension of what goes on in the human biochemistry. I often sigh with dismay when I read the short-sighted conventional medical articles in the International New York Times. One does not know whether to laugh or cry when reading most of those articles–both reactions are often appropriate.

    As I myself had polycystic ovary syndrome and very bad fibrocystic breasts, I would like to comment on some things which I found which were quite helpful toward resolving the situation.

    Here is an additional piece of interesting information I have found due to the research of Dr. Al Plechner, DVM., in animals, and the resulting cases of women who have convinced their practitioners to help them try a human version of the protocol he developed during fifty years of work in animals. Vitally important is that women’s total estrogen should be checked–total estrogen– not just adding up the levels of the types of estrogens normally checked. In my case my ovarian estrogens all tested normal, but my total estrogens were at 100 when they should have been 20–representing a massive estrogen overload despite the fact that I am 62 years old and am in menopause!!! I have also seen a total estrogen overload of 200 in a woman with breast cancer.!!! Her doctors had given her estrogen in menopause as her ovarian estrogens were low, but they had not checked for her total estrogen– which was high!!! The total estrogen test includes the estrogens produced by the adrenals due to pituitary hyperstimulation in the presence of poor adrenal function. Ordinary estrogen tests do not measure all of the adrenal source estrogens. Animals with poor adrenal function will usually have pituitary hyper-stimulation which can raise the production of sex hormones–estrogen and testosterone. Almost all animals with the adrenal defect will have high total estrogen. Some of them will have high testosterone. Dr. Brownstein and Dr. Plechner together tested six women with breast cancer for high androgens and all of them had high androgens. The evidence is building that the same thing happens in people as happens in the animals. Often this situation will bind the thyroid hormone’s activity, even if normal levels of thyroid hormone are present. While, as you say, in your excellent piece on adrenal damage that this damage is created by damage to the oxygen systems at the molecular level, and the resulting loss of oxygen homeostasis, it then becomes a major part of the problem as the bodies hormonal commands imbalance. In Dr. Plechner’s research the immune system is always clearly impacted by this, and I am sure you would agree, due to having read your work on oxygen homeostasis and the immune system. Re-balancing the hormones will help. Usually physiologic doses of cortisone, together with any needed thyroid hormone will make a difference in beginning to balance out the hormonal situation– by helping to restore the proper hormone balance to help create oxygen homeostasis. There is another interesting marker. I also had a genetic tendency toward low IgA as did my husband and a number of other people who have tried the hormone balancing protocol. The total IgA should be checked, as low IgA is a good marker for when the undefended, inflamed intestine will not have good gut absorption of oral cortisone, and of many of the other therapies. Oil-based hydrocortisone capsules cortisone will absorb better, but often if the IgA is very low, patients require an initial therapy of a few cycles long acting injectable cortisone with their bowel detoxifying protocols before they will absorb oral cortisone. This will move the IgA levels upward and help to resolve the gut inflammation. In the presence of very low IgA the oral therapies do not absorb well, so it is essential to use the low IgA marker, and several cycles of long acting injectable cortisone at physiologic doses together with any needed thyroid hormone to be sure the cortisone is metabolized every 24 hours and does not accumulate in the body to become a pharmacologic dose. The low IgA will usually rise to normal within two cycles of injectable long-acting cortisone. Then oral therapy will work in most patients.

    One of my woman doctors Dr. Bobbi Spurr, who has worked extensively on these types of problems used a therapy on me which literally helped me get into menopause without a hysterectomy. Satrting slightly before, and continuing during my menstrual cycle each month she had me take very large doses of enteric coated enzymes on an empty stomach in order to make them enter the blood stream instead of just digest food . In my case I took Wobenzyme with very large amounts of water for protection of the digestive tract as the enzymes can be very aggressive. as per Dr. Spurrs instructions, I took three large glasses of water with each dose, and took the enzymes three times a day. The enzymes re-absorbed any bleeding form the cysts, so I was able to avoid a surgical emergency from the cysts bleeding, and avoided having to have a hysterectomy. At the time I did not know about the hormonal protocol using physiologic doses of cortisone and thyroid to help re-balance the situation.

    Obviously, women should always see qualified practitioners, the problem is that there are very few of them, so the situation is very difficult.

    However, these problems are treatable and it is essential to do so. I believe the estrogen overloads combined with the immune deregulation they cause due to the underlying molecular biochemistry is losing its oxygen homeostasis, also sets the stage for added cancer risk. That that makes the resolution of the base problems even more vital. I believe the hidden estrogen overloads, and androgen overloads are very likely contributing to the epidemic of breast cancer. As your very fine book on cancer points out–we are living in a chemical soup which includes many estrogen and testosterone mimicking chemicals. A huge overload of estrogens and testosterone produced by our damaged adrenal glands due to pituitary hyperstimulation when active cortisol is inadequate is tipping the balance further against us. We can also defend by tipping the hormonal balance back to a more normal state.


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