De-Mystifying Disease | Majid Ali MD
The Greasy Build up-Detergent Model of Disease
The spectrum of diseases in medical textbooks is vast. Is there any common underlying energetic or metabolic derangement that applies to most, if not all, acquired diseases? Is there a workable simplicity that can help us cope with the seemingly mad complexity of diseases? Is there a unifying model of disease with an explanatory power for all acquired diseases? Can such a model be supported by sound scientific evidence? My answer to these questions is an unequivocal yes. Simply stated, it is The Grease and Detergent Model of Disease.
Every living cell breathes oxygen and produces waste and cellular debris. In this process, fats turn rancid, sugars become sticky, and protein are pulped (chains of amino acids making forming proteins are cut, turned, and twisted). In health, these substances are rapidly cleared so that cells can breathe oxygen, expel waste and toxins, and stay healthy and happy. In disease states, rancid fats, sticky sugars, and pulped proteins accumulate on cell membranes. Sometime ago, I introduced the term cellular grease for the layer of such materials that builds on cell membranes in all diseases.
Nature also created a system of grease-cutters—detergents, in common language—that remove cellular grease and allow cells to breathe again. The primary detergent in the human body is oxygen. Secondary detergents are hydrogen peroxide, superoxide, singlet oxygen, nitric oxide, and others. The third layer of detergent is provided by enzymes. The Grease-Detergent Model of Disease explains the beginning of all acquired disease with either excess of grease or deficit of detergents.
Greasy Cooking Pot
A cooking pot becomes greasy when oil is used to cook food in it. Common sense tells us that cooking fresh food in a pot that is greasy from previous cooking cannot be healthy. Such grease contains some oxidized and rancid fat. If new foods were to be cooked in it, all the fat in the grease will become heavily oxidized and toxic. In addition, the toxic grease will increase the rate at which the new oil will be oxidized and rendered unhealthy. This process can be considered as “chain- oxidation,” in which increasing amounts of oxidized fats escalate the rate of oxidation of unoxidized fats. No one wants to cook again in a pot that is greasy from previous cooking, and therefore soap detergent is used to clean the greasy pots.
When the cells in the body are covered with too much sugar and acids, they also become covered with grease. Greasy foods cover the cells with more grease. The greasy cells need to be cleaned. Nature made oxygen the most important detergent in the body. Oxygen combines with hydrogen to make hydrogen peroxide, which is another good detergent for greasy cells.
After rain, leaves on trees are clean and shiny. Days later, unclean and polluted air makes them dirty. It is the same way with cells in the body. Clean blood with much oxygen keeps the cells clean. When the blood becomes dirty with too much sugar, bad fat, and pollutants from the air, it also makes the cells dirty and greasy.
Drugs are beneficial when they are really necessary. It is not fully appreciated that drugs cause build-up of grease on and within cells. All so-called side effects of drugs, in reality, are caused by build-up of grease on various types of cells in the body. It is important to recognize that the grease-building effects of two or more drugs used concurrently are more than the sum of grease built by their use individually. Let us consider the use of mind-altering drugs for U.S. children who are given three times as many drugs as children in Europe. Parents of such children need to recognize this when they consider the issues of optimal body weight, obesity, insulin resistance, pre-diabetes, and Diabetes. Such drugs add to the burden of unhealthy foods, pollutants, and stress on children.
Chemistry and medical textbooks consider oxygen to be a substrate—a substance that other substances act upon—in body chemistry. For example, it is stated that hemoglobin in the blood picks up oxygen in the lungs and delivers it to tissues. Oxygenase enzymes are said to add oxygen to compounds catalyzed by them. Hypoxia-inducible factors (HIFs) are supposed to sense the presence of oxygen. Mitochondria are considered to utilize oxygen. Chemoreceptors are assigned the roles of recognizing the concentrations of oxygen in blood and cells.
I do not consider oxygen to be passive. It is not merely a substrate for enzymes, sensing proteins, mitochondria, or chemoreceptor cells. Oxygen is an organizer, not just an element to be harnessed. For reasons of crucial clinical significance in medicine, oxygen should be clearly seen for what it is: a maker, a shaker, and a mover. In this light, oxygen “rides” large protein complexes, such as hemoglobin. Oxygen rearranges protein complexes, such as those included in the HIF family. Oxygen drives electron and proton chain reactions in structures within the cells (organelles), such as mitochondria. Oxygen awakens cells: chemoreceptors. Oxygen activates cells, such as in glomus cells in the aorta and the carotid arteries. For all of the above reasons, I consider oxygen to be the primary grease-cutter in the body.
To underscore the primacy of oxygen in the health of cell membranes, I cite the case of a crucial family of proteins. The fluid membranes of animal cells—from humans to horses to hummingbirds—carry members of a family of proteins called G-proteins.* These proteins sense diverse signals—light, odors, electromagnetic energy, lipids, proteins, hormones, and chemicals—and transmit the information to initiate cellular functions. Grease on membranes impede or block all such functions. Additionally, cell membranes also contain receptors and channels** —passages for the entry and exit of calcium, magnesium, potassium, and sodium—which do not function when the cell membranes are chemicalized and hardened.
When cell membranes are covered with excess grease due to the weakened grease-cutting role of oxygen, G-proteins fail to maintain their diverse functions related to membrane receptors and channels. Nearly all diabetes drugs work by restoring the functions of these receptors and channels. Such commonly used drugs include Cardizem, Norvasc, Cozaar, Vasotec, Diovan, and others. I will show how all membrane dysfunctions can be eventually related to oxygen dysfunction.
The Dysox Model of Disease Provides the Scientific Basis of The Grease-Detergent Model of Disease
Some years ago, I proposed The Dysox Model of Disease as such a unifying model of disease. It is based on my assertion that altered oxygen signals and impaired oxygen-driven cellular energetics are the fundamental abnormalities in all acquired diseases. Since then, I have published over 25 papers marshalling strong scientific evidence for the dysox basis of diabetes, hypertension, heart disease, stroke, kidney failure, pain syndromes, chronic fatigue syndrome, osteoporosis, Alzheimer’s disease, and others.
The Dysox Model of Disease provides the scientific underpinning of The Grease-Detergent Model of Disease
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