Evidence of Oxygen Model of Heart Disease
“We all know that oxygen is crucial for survival, but it is intriguing to know that the same oxygen can be used like a drug to treat disease”
Periannan Kuppusamy, PhD, professor of radiology at Geisel School of Medicine at Dartmouth
A core tenet of my Oxygen Model of Heart Disease is that heart attacks are, first and foremost, problems of the circulating blood, not of coronary artery walls. This model also predicts that heart health program directed at coronary arteries will have limited, if any, benefits if they do not effectively address the matters of the health of the circulating blood.
Specifically, in the context of coronary artery plaques being the primary cause of coronary heart attacks, the model predicts that drugs that inhibit inflammation in the coronary plaques will not prevent heart attacks. A clear statement that this prediction proved right was published by New England Journal of Medicine on May 1, 2014. Consider the following quote from the Journal article on this date:
“Conclusions – In patients with stable coronary heart disease, darapladib did not significantly reduce the risk of the primary composite end point of cardiovascular death, myocardial infarction, or stroke.” New England Journal of Medicine. May 1, 2014, (2014; 370:1702-1711).
Now a study published in EMBO Molecular Medicine, a Dartmouth researcher found that dying heart cells are kept alive with spikes of oxygen.
During a heart attack when the flow of oxygen-rich blood to a section of the heart is interrupted, and not quickly restored, heart muscle begins dying. Deprived of oxygen and other essential nutrients, cell death continues occurring over a period of time leading to progressive loss of heart function and congestive heart failure.
Current therapies are not effective at limiting cell loss—they only slow down the progression of congestive heart failure.
Periannan Kuppusamy, PhD, professor of radiology at Geisel School of Medicine at Dartmouth, found that dying heart cells still contain enough oxygen for metabolism, and additional short-term spikes of oxygen keep the cells alive and active.
His research team used an animal model of acute myocardial infarction and discovered that daily administration of a higher concentration of oxygen for a short period of time each day induced spikes in myocardial oxygenation, which prevented myocardial injury.
“We all know that oxygen is crucial for survival, but it is intriguing to know that the same oxygen can be used like a drug to treat disease,” Kuppusamy says.
Curious about the molecular mechanism of oxygen in treating myocardial injury, he began examining the effect of oxygen on p53, a transcription factor that regulates cell cycle and triggers programmed cell death. To his surprise he saw the ‘oxygen spikes’ altering the function of p53 from a death-inducing protein, to promoting transcription of genes that help dying cardiac cells survive.
My Oxygen Model of Coronary Heart Disease is an extension of my Oxygen Model of Health and Disease. It is a unifying model that explains all aspects of coronary heart disease—causes, clinical course, consequences, and control—on the basis of disturbed oxygen function. The most important among these compromised and/or blocked functions are:
- oxygen signaling
- oxygen’s ATP energy generation
- oxygen’s detergent functions
- oxygen’s cellular detox functions
- oxygen-regulated cell membrane and matrix functions
- oxygen’s cellular repair roles
The Oxygen Model of coronary heart disease provides a simple model that allows physicians to reduce complexities of diverse clinical syndromes into a workable simplicity.
This model predicts that ongoing research will reveal that components of acidosis (excess acidity), oxidosis (increased oxidative stress), and CUD (clotting-unclotting dysequilibrium) will be found to play important roles in the pathology and clinical features of coronary heart disease.
Oxygen, Heart and Healing
If you have never taken herbs and spices for a healthy heart, please pick two from my list in this e-essay and take them in weekly rotation.
If it were my choice, I pick Green Tea and ginger tea with a dash of turmeric
First Things First
– Coronary heart disease is a plaque problem before it becomes a heart attack.
– Coronary heart disease is an inflammatory problem before it becomes a plaque problem.
– Coronary heart disease is an excess acidity and oxyradical problem before it becomes an inflammatory problem.
– Coronary heart disease is an oxygen problem before it becomes an excess acidity and oxyradical problem.
In most cases, insulin and adrenaline toxicities also set the stage for heart attacks. However, first and foremost, these are also oxygen problems. If this is true, some might ask, why don’t doctors explain these simple truths to their patients? The answer: science is dumbed down and doctors cannot think independently. If some herbs improve oxygen homeostasis, why don’t doctors use them? The answer: science is dumbed down and doctors do not recognize that The New England Journal of Medicine is a champion of drugs, not herbs.
A Simple Question
Here is a question: What is the best way to get more oxygen? The answer is at the end of this e essay.
Herbs for a Healthy Heart
Below, I list my suggestions in order of their clinical efficacy based on my experience.
All these herbs are generally available at most health food and ethnic market stores.
Clot busting (antithrombotic) Herbs
Turmeric, cayenne, celery, garlic, ginger, Chinese skullcap, Forskohl’s coleus, and horse chestnut.
Hawthorn berry (as tincture), blood root, goldenseal, basil, black pepper, barberry, cloves, cucumber, garlic, genipap, goldenseal, goldthread, grapes, horse chestnut, ouabain, and yoko.
Blood Cleansers (through anti gut fermentaion effects)
Astragalus, burdock root, echinacea, goldenseal, pau D’Arco, olive leaf, and oregano.
Pro blood Flow
Green tea, flax seeds (freshly ground), black pepper, barberry, and cucumber.
Cat’s claw, avocado, chilgoza pine, thyme, and cantaloupe.
Bromelain from pineapples and other botanicals.
Start Low and Build Slow for Becoming Your Own Primary Physician
The above principle is more relevant to the subject of herbs for the heart than it is for other subjects. Safety first. Please know it takes time, sometimes several months to learn to be one’s own authentic primary physician. So, please do not stop your heart or blood pressure medications on your own. Study the information given below, pick a few herbs at a time, use them in small amounts and in weekly rotation until you can observe their effects. Discuss the effects you observe with your cardiologist.
Beware of Pseudoscience
The body of literature about clinical uses of various herbs for cardiovascular disorders is now enormous—and rapidly growing. I do not readily accept the results of blinded and controlled clinical trials about the safety and clinical efficacy of individual herbs and phytofactors since they suffer from the following serious conceptual and methodological flaws:
1. Clinical studies of single herbs are conducted for short periods of time—extending from several weeks to some months—and are wholly inadequate for providing reliable information for their long term (in years) use;
2. Clinical trials of single herbs are conducted with a small number of subjects, and no consideration is given to crucial issues of biochemical individuality of the patients to which the conclusions drawn are applied;
3. Of necessity, clinical trials involving single herbs fail to explore the synergistic and/or antagonistic effects of other herbs and nutrients prescribed in an authentic clinical setting; and
4. Clinical trials are based on the prevailing one disease/one drug model. This model is intellectually invalid and clinically irrelevant.
Beware of Fear
Fear is the instrument of terror used by pharmaceutical companies to push drugs. It is also the instrument of terror used by hospitals and surgeons who profit from “plumbing” procedures for the heart. Ethical cardiologists find it increasingly difficult to counter the pernicious influences of corporate monsters who control their professional journals and associations. The only true weapon people have against the monsters is knowledge and understanding. For understanding to be authentic, it has to be liberating. I hope to offer some liberating information about herbs for the heart in this e essay.
Bottom line: Holism and empiricism is the way. I present this subject at length in Nature’s Preoccupation With Complementarity and Contrariety (2001) the first volume of The Principles and Practice of Integrative Medicine.
I close this e essay with the question I asked earlier: What is the best way to get more oxygen? The answer: slow Limbic Breathing (Feather Breathing). If slow breathing improves oxygen supply to tissues, why don’t doctors prescribe it? The answer: science is dumbed down and doctors cannot distinguish between New Age fog and serious scientific argument.
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