Cancer Drugs That Boost Immunity – The Promise of Nivolumab and Related PD-1 Drugs

Majid Ali, M.D.

We hope soon we will have drugs that destroy cancer and empower the body’s own defense system at the same time. This is an old hope which has been dashed so many times that the very mention of it brings doubt, even sarcasm. And yet we must keep this hope alive.

One person whose name comes to mind on this subject is William B. Coley, a New York surgeon, who in the late 1800s, reported a disappearance of cancer in a patient who had a severe bacterial infection. He went on to injecting microbial preparations into his cancer patients and claimed some success. This became the “Coley vaccine,” which was supported by some and forcefully disputed by others. In recent years, among many other approaches taken to develop a drug that kill cancer cells and strengthen immunity involves a protein called PD-1 (programmed death 1). Some evidence suggests that PD-1 and its companion substances (ligands) negatively affect immune responses. Early and limited studies show that antibodies that target PD-1 boost the immune system and destroy cancer. Specifically, one such antibody, nivolumab, produced complete or partial responses in certain types of cancers of the lung and kidney, and melanoma. I point out that in these studies colon and pancreatic cancer did not respond to this drug.

Living With and Beyond Cancer – Intro Majid Ali MD from Majid Ali on Vimeo.

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The Oxygen Protocol for Cancer

My Oxygen Protocol for Cancer is also based on the same promise of controlling cancer by therapies that powerfully boost immunity by restoring and enhancing oxygen homeostasis. Later in this article, I offer more information on the model described fully in the two volumes of my cancer book. Now to some news on the subject.

Promising New Cancer Drugs Empower the Body’s Own Defense System

The above was the title of a front-page story on the business section of The New York Times on June 3, 2013. This means that the Times recognized it to be first a business story and only then a medical report. No surprise there. Consider the following quote from the Times’ article: The new drugs work by disabling a brake on the immune system called the programmed death 1 receptor, or PD-1. And although the data presented at the meeting was from the earliest stage of testing only, the drugs were the center of attention here, with some doctors predicting that cancer treatment was about to shift.”

Next consider another quote from the same article: “Analysts, who predict billions of dollars in sales, are trying to determine which of the three front-runners—Merck, Bristol-Myers and Roche—have the best drug and how soon the drugs could reach the market. Some think it could be as early as a year and a half from now.The excitement has spread to Wall Street. Shares of Merck and Bristol-Myers Squibb, which are developing such drugs, rose more than 3 percent on Monday after data from their studies was presented over the weekend at the meeting of the American Society of Clinical Oncology.”

The Times article refers to the case of malignant melanoma of Dr. Therese Bocklage, an Albuquerque pathologist, who took Merck’s experimental PD-1 inhibitor, lambrolizumab, as part of a clinical trial since January 2012. Her tumors disappeared. Great news! “If I had had this turn up not last year but six years ago, most likely I’d be dead,” she said. She must know, as I, a pathologist myself, do that melanoma ranks high near the top of cancers which are likely to respond to such a therapy.

The Times also recognize what I have sadly recognized for half a century with the following words: “But there are reasons to be cautious. This is cancer, after all. Many other hoped-for miracles have failed to materialize. This is a conference that has hailed drugs that extend lives by only a few weeks as breakthroughs. “

Excitement about “the immune system boosting” comes cheap. Consider the drug therapies that were called miracles for patients with rheumatoid arthritis, sarcoidosis, lupus, scleroderma, and multiple sclerosis. The real tragedy here is that the promise of immune-boosting drugs is blinding doctors to natural remedies that are generally highly effective for these immune disorders, and are in general far more valuable in controlling cancer.

Oxygen Model of Cancer

My Oxygen Model of Cancer is an extension of my Oxygen Model of Health and Disease. It is a unifying model that explains all aspects of cancer—causes, clinical course, consequences, and control—on the basis of disturbed oxygen function. The most important among these compromised and/or blocked functions are: (1) oxygen signaling; (2) oxygen’s ATP energy generation; (3) oxygen’s detergent functions; (4) oxygen’s cellular detox functions; (5) oxygen-regulated cell membrane and matrix functions; (6) oxygen’s cellular repair roles.

This model predicts that ongoing reserach will reveal that components of acidosis (excess acidity), oxidosis (increased oxidative stress), and CUD (clotting-unclotting dysequilibrium) will be found to play important roles in the pathology and clinical features of cancer.

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● Cancer Seminar 1 – The First Encounter
In this 40-minute video seminar, Professor Majid Ali, M.D. addresses the crucial issues of coping with the initial stress of cancer diagnosis, second opinion on pathology diagnosis, finding the right professionals for advice, learning about the treatment options, and making the right choice of doctors as well as the optimal treatment plan. 
● Cancer Seminar 2 – The Oxygen Model of Cancer
In this 40-minute video seminar, Professor Majid Ali, M.D. presents his Oxygen Model of Cancer and describes its crucial clinical significance.  The core of this model is that a cancer cell is a fermenting cell. The Oxygen Model of Cancer is an extension of his Oxygen Model of Health and Disease.
● Cancer Seminar 3 – Should You Have Surgery for Cancer?
In this 40-minute video seminar, Professor Majid Ali, M.D. discusses when it is a grave mistake to unduly delay surgery for the early removal of cancer mass and when surgery is not an acceptable approach. He tsrongly recommends not only consulting an experienced surgeon but also to consult a senior and experienced pathologist for making an informed intelligent decision.
● Cancer Seminar 4 – Radiotherapy for Cancer
In this 50-minute video seminar, Professor Majid Ali, M.D. discusses when it is a grave mistake to refuse radiotherapy for treating cancer and when radiotherapy is not an acceptable approach. He strongly recommends not only consultation with an experienced radiotherapy specialist but also with an experienced pathologist for making an informed intelligent decision. 
● Cancer Seminar 5 – Chemotherapy – Should You Take It?
In this 45-minute video seminar, Professor Majid Ali, M.D. offers valuable information to assist people to make informed decision of whether or not to take chemotherapy for cancer. He explains the crucial difference between overall survival (OS) and the falsely claimed benefits of “progression-free survival (PFS) without any true survival benefits of toxic chemotherapy.
● Cancer Seminar 6 – Oxygen Protocol for Treating Cancer
In this 30-minute video seminar, Professor Majid Ali, M.D. outlines his Oxygen Model of Treating Cancer. He considers it essential for all patients being treated with surgery, radiotherapy, or chemotherapy. Oxygen therapies integrated in this Protocol are mandatory for restoring and strengthening oxygen’s cancer-fighting roles, including boosting the immune system.
● Cancer Seminar 7 – Foods for Controlling and Killing Cancer
In this 40-minute video seminar, Professor Majid Ali, M.D. describes the principles of sound nutrition for creating metabolic conditions that strength the body’s oxygen-regulated cancer-killing mechanisms. He explains why some food are good and others not so. His dietary guidelines are easy to follow. He illustrates his main points with specific examples of desirable food choices and offers a simplied and highly nutritious anti-cancer diet plan.

● Cancer Seminar 8 – Cancer Killing Spices
In this 40-minute video seminar, Professor Majid Ali, M.D. informs about his preferred spices to be included in his integrative plans for treating cancer, including turmeric, ginger, garlic, cumin, coriander, cinnamon, and cardimum. He explains their anti-inflammatory, antioxidant, acid-fighting, clot-preventing, and other benefits. Specifically, he explains how spice therapies should be rotated to maximize their cancer-fighting roles.

Living With and Beyond Cancer
In these 40-minute video seminar, Professor Majid Ali, M.D. presents a subject which he considers to be of central importance after the diagnosis and initial treatment of cancer. He introduced the phrase “Living With and Beyond Cancer” for a way of living with cancer as fully and functionally as possible with equanimity. It is to accept fear, anxiety, and life-limitations , until one reaches a state in which these are not issues most of the time. One does not take this journey without many missteps and faltering. This life of learning, understanding, and knowing is usually difficult in the beginning and becomes easier with continued spiritual growth and enlightenment. Cancer diagnosis is expected to unleashes panic, which leads to two paths: a path of continued panic and a path of Living With and Beyond Cancer.
● Cancer CLL Leukemia
In this 40-minute video seminar, Professor Majid Ali, M.D. discusses the causes, clinical features, types, and biologic course of CLL (chronic lymphocytic leukemia) and its variants called SLL and PLL). He addresses the important question of when not to do chemotherapy and when to consider it.. He describes his unifying Oxygen Model of Cancer, and offers guidelines for simple, safe, and effective natural therapies for boosting the immune system for controlling CLL, SLL, and PLL.
● Cancer- Fermentation-Inflammation Connections Seminar
In this 40-minute video seminar, Professor Majid Ali, M.D. brings together the basic scientific facts of metabolism of cancer, fermentation, and inflammation. He explains his reasons why in the context of cancer, the word inflammation should be replaced with fermentation. Rather than inform, the term inflammation creates layers of darkness. By contrast, the term fermentation clearly indicates lack of funtional oxygen and rapid buildup of acids, alcohols, and toxic byproducts of interrupted metabolism of sugars, fats, and proteins to release ATP energy. This knowledge provides the scientific basis of intelligent and effective natural therapies to be employed alone or with surgery, and when necessary chemo and radiotherapy.

● Cancer – False Cancer, Unnecessary Surgery and Chemotherapy Seminar
In this 40-minute video seminar, Professor Majid Ali, M.D. addresses the crucial subject of when something is considered to be cancer but in reality is not. He cites specific examples from his four decades of experience as a surgeon, pathologist, and integrative physcian to illustrate his main points. He underscores the importance of second pathology opinion and opinions from integrative physicians. A July 2013 report in the Journal of American Medicine fully validates his observations and thinking.

● Cancer Pain Control Seminar 
In this 35-minute video seminar, Professor Majid Ali discusses seven core aspects of cancer pain: (1) control of cancer pain is self-compassion for the patient; (2) control of cancer pain is physician’s compassion for the patient; (3) a cancer cell is a fermenting, oxygen-shunning cell; (4) every pain is some cells’ cries for oxygen; (5) stress and dehydration worsen cancer pain, as they do all other types of cancer; (6) natural oxystatic and anti-inflammatory remedies must be considered as the primary approach to the problem; and (7) the use of pain killers should not be opposed if natural therapies do not give effective pain control.

Cancer Book – Volume 1 KINDLE > BOOK:
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Volume 1 of Dr. Ali’s two volume cancer book series.
In patient advocacy, a physician’s first commitment must be to the truth, the second to hope. Sadly, I found that not to be true in oncology literature or in the writings of the so-called holistic doctors who claim to cure cancer.

I found the realities of cancer in my patients who overcame their cancers, who live with cancer, and in those who died with cancer—angry and frightened initially, often in despair later, nearly always with awe-inspiring courage close to the end.

Cancer Book – Volume 2 IPAD/NOOK > BOOK:
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Cancer Book – Volume 2 – PDF > BOOK:
About this item:
Chapters in theses works include:
1. Restoring Bowel Health
2. Restoring Liver Health
3. Restoring Blood Health
4. Alkalizing therapies
5. Enzyme therapies
6. Oxygen therapies
7. Limbic breathing
8. Sleep
9. Spice Medicine and much more


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