Insulin – An Evolutionary perspective

Majid ali, M.D.

Next to oxygen, I recognize Nature’s intelligence, majesty, and economy more in insulin than in any other substance in the body. Insulin toxicity is a primal threat to human health. This chapter has three core messages concerning cellular toxicity caused by excess of this quarterback of metabolism:

☞ It occurs in all individuals with insulin disorders—insulin resistance, hyperinsulinism (excess insulin), pre-diabetes, Type-1 diabetes, Type-2 diabetes, and gestational diabetes;
☞ It is seldom, if ever, duly recognized in the dogma of the American Diabetic Association (ADA); and
☞ It must be understood clearly to prevent and/or reverse diabetes.

Evolution’s Intelligent Design and Insulin

Evolution designed insulin to be the primary organizer of the body’s economy under the direction of the Oxygen King. It stores energy in times of scarcity and expends it in times of abundance. It assures “metabolic rest and recovery” at night and a state of “metabolic awakening” during the day.

In health, insulin is a guardian angel of life; in excess, it is a molecular monster. This is a crucial point since nearly all cases of Type 2 diabetes start out with excess insulin (hyperinsulinism). Diabetes is primarily misunderstood and mismanaged because insulin toxicity is not taught nor recognized in clinical guidelines of the ADA. Nearly all untruths and outright falsehoods about the cause of diabetes and most clinical errors in caring for people with insulin disorders can be traced to the ADA’s neglect of the long-term dangers of insulin toxicity. “Eat whatever you want, and we will cover it with insulin” was the advice that many of my patients received. Insulin toxicity that occurs almost invariably with this approach was not mentioned.

Insulin, outside its narrow normal range, is a toxin. People who take insulin injections soon discover one aspect of this toxicity. They commonly suffer from episodes of weakness, nausea, and heart palpitations due to low blood sugar levels (hypoglycemia) caused by
inappropriate doses of insulin. Troublesome as such reactions are, I do not consider this to be the major source of insulin toxicity. Far more dangerous aspects of insulin toxicity are the unrecognized long-term disruptions of oxygen-regulated health-preserving systems of the
body. Specifically, insulin toxicity causes derangements of cell membranes, matrix (glue that hold cells together), and mitochondria —the three-M components of The Oxygen Model of Diabetes presented in chapter 6. Insulin inflicts its three-M damage by its potent pro-inflammatory, anti-immune, pro-obesity, and vascular effects.

Nature rests the insulin-producing cells in the pancreas at night. In healthy people, the fasting blood glucose level ranges from 75 to 90 mg/dL and the insulin level is often less than two units. This means that little, if any, insulin is required to keep blood sugar in the fasting range. Most laboratories consider a fasting blood insulin level as high as 25 units as “normal”—the upper limit of the normal range of Quest, a major national laboratory, is 28 units (uU/mL). I consider it a serious error since it hides significant abnormalities in insulin regulation. Indeed, a fasting insulin level of over 10 units, in my view, represents a clear evidence of excess insulin and insulin waste. I consider a fasting insulin level of over 20 units as clinically significant hyperinsulinism, indicating a state of insulin toxicity.



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