The Oxygen Model of Thyroid Reverse T3 State

Majid Ali, M.D.

In health, T4 thyroid hormone is converted into much more potent T3 thyroid hormone. With incremental chemicalization of the human habitat, as well as stress and anger, the problems associated with the T4-to-T3 conversion are becoming more common. Specifically, chemicalized cells convert T4 to reverse T3 (mirror-image form of the hormone). Reverse T3 is metabolically inactive and yet it binds with thyroid receptor proteins embedded in the cell membranes and disrupts the functions of whatever normal T3 is available. I designate this state as “the Reverse T3 State.”  Since the syndrome is caused by cellular toxicity, it cannot be treated with thyroid hormone therapy alone.

I propose The Oxygen Model of Reverse T3 State as a unifying model that recognizes disturbances of oxygen functions as the fundamental commonality of all elements that cause T4-to-T3 conversion abnormalities seen in the syndrome. For treating the syndrome, this models offers a workable simplicity to cope with the complexities of the reverse T3 thyroid syndrome. It requires that all threats to oxygen homeostasis (inflammation, infections, chemical toxicity, stress) be recognized.

Treatment of Reverse T3 Syndrome—A case Study

In the summer of 2011, a 36-year-old man consulted me for headache, generalized itching, adverse food reactions, gastritis-GERD complex, fatigue, anxiety, and underactive thyroid (hypothyroidism).
Ten years earlier, he experienced severe family and work stresses, and developed an ulcer in the stomach. Three years later he developed kidney stones which recurred two years later. Four years prior to consulting me he developed hypothyroidism for which he was prescribed Levoxyl (75 mcg). He obtained limited initial benefit. His general condition continued to worsen in spite of Levoxyl dose adjustments from 75 to 100 to 75 mcg.

On examination, he was dehydrated, tired, and anxious. A percussive liver tenderness was elicited with gentle tapping. No nodules were found on the thyroid gland. The abnormalities of his thyroid blood tests are shown in the Table (note the abnormal reverse T3 test).

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