Leukoplakia – Cause and Treatment

Majid Ali, M.D.

What did my microscope teach me about leukoplakia? What do medical textbooks teach me about leukoplakia? Most importantly, what did my patients teach me about leukoplakia? I answer the questions in this order and address the crucial matter of leukoplakia turning into cancer.

What did my microscope teach me about leukoplakia?

Leukoplakia is a chronic condition characterized by discrete areas of thickened, roughened, and whitened mucous membrane lining various organs. The layers of cells multiply and are infiltrated with inflammatory cells. With time, the cells become irregular in outline and their nuclei become enlarged, darker, atypical. These changes indicate a precancerous state. If neglected and allowed to progress, such cells become cancerous, usually after several years.

What do medical textbooks teach me about leukoplakia?

The cause of leukoplakia is unknown. In some cases, tobacco, either smoked or chewed, can cause persistent irritation of mucosal lining of the oral cavity and cause it. The term “candidal leukoplakia” is used when leukoplakia develops in patients with oral or systemic candidiasi. Chronic local irritation caused by ill-fitting dentures seem to predispose local tissues to its development. There is no known satisfactory treatment for it except surgery.

What did my patients teach me about leukoplakia?

Leukoplakia develops as a consequence of altered states of bowel ecology, especially the issues of gut fermentation, excess mycotoxin production, leaky gut state—all caused by sugar and antibiotics abuse, undiagnosed and untreated mold allergy, food allergy and intolerance, parasitic infestations, and problems of indigestion and absorption. These factors cause: (1) excess acidity in the oral cavity and other corrosive fluids in the urinary and genital tracts; (2) increased free radical activity damage; (3) thickening of bodily fluids that interfere with optimal cellular breathing; and (4) biofilm formations over mucous linings. Biofilms are slimy layers of tangled proteins, rancid fats, and sticky sugars in which are embedded diverse microbial species that protect each other from natural and synthetic antibiotics.

The above is my explanation of the fact that most tobacco smokers do not develop leukoplakia. So, tobacco is a secondary factor. The same is true of viral and bacterial populations which are present in all oral cavities and genital and urinary tracts.

Leukoplakia is most commonly found on the insides of the cheeks, and the surfaces of throat. Less commonly, it involves various areas of the genital and urinary tracts.

Cancerous Change in Leukoplakia

In my experience, leukoplakia can be reversed with nondrug measures that restore oral hygience and bowel, liver, and blood ecosystems. So I advise my patients to think holistically and act integratively to restore the integrity of these ecosystems and not obsess with the development of cancer. The treatment of advanced lesions is surgical removal.


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